CHEBI:61076 - belinostat

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name belinostat
ChEBI ID CHEBI:61076
Definition A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Sandra Orchard
Supplier Information
Save molfile Download Molfile
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C15H14N2O4S
Net Charge 0
Average Mass 318.34800
Monoisotopic Mass 318.067
InChI InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
InChIKey NCNRHFGMJRPRSK-MDZDMXLPSA-N
SMILES ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
Roles Classification
Biological Role(s): EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing belinostat (CHEBI:61076) has role antineoplastic agent (CHEBI:35610)
belinostat (CHEBI:61076) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
belinostat (CHEBI:61076) is a hydroxamic acid (CHEBI:24650)
belinostat (CHEBI:61076) is a olefinic compound (CHEBI:78840)
belinostat (CHEBI:61076) is a sulfonamide (CHEBI:35358)
IUPAC Name
(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
INN Source
belinostat KEGG DRUG
Synonyms Sources
(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide IUPAC
N-Hydroxy-3-(3-(phenylsulfamoyl)phenyl)prop-2-enamide ChemIDplus
PXD101 SUBMITTER
Database Links Databases
Belinostat Wikipedia
D08870 KEGG DRUG
View more database links
Registry Numbers Types Sources
10087570 Reaxys Registry Number Reaxys
414864-00-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
23382909 PubMed citation CiteXplore
23475695 PubMed citation CiteXplore
23644904 PubMed citation CiteXplore
24020452 PubMed citation CiteXplore
24369094 PubMed citation CiteXplore
24800886 PubMed citation CiteXplore
24918834 PubMed citation CiteXplore
25134672 PubMed citation CiteXplore
25189481 PubMed citation CiteXplore
25368524 PubMed citation CiteXplore
25389633 PubMed citation CiteXplore
25404094 PubMed citation CiteXplore
25433307 PubMed citation CiteXplore
25446119 PubMed citation CiteXplore
25483416 PubMed citation CiteXplore
25611313 PubMed citation CiteXplore
25673888 PubMed citation CiteXplore
Last Modified
04 March 2015
General Comment
2011-01-25 Inhibits both class I and class II histone deacetylases. See also http://www.cancer.gov/drugdictionary/?CdrID=454583