CHEBI:52993 - lormetazepam

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ChEBI Name lormetazepam
ChEBI ID CHEBI:52993
Definition A 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:52992, CHEBI:31782
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Formula C16H12Cl2N2O2
Net Charge 0
Average Mass 335.18500
Monoisotopic Mass 334.028
InChI InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3
InChIKey FJIKWRGCXUCUIG-UHFFFAOYSA-N
SMILES CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc12
Roles Classification
Biological Role(s): GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
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ChEBI Ontology
Outgoing lormetazepam (CHEBI:52993) has role sedative (CHEBI:35717)
lormetazepam (CHEBI:52993) is a 1,4-benzodiazepinone (CHEBI:35500)
lormetazepam (CHEBI:52993) is a organochlorine compound (CHEBI:36683)
IUPAC Name
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
INN Source
lormetazepamum ChemIDplus
Synonyms Sources
(±)-Lorazepam DrugBank
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one ChemIDplus
7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one NIST Chemistry WebBook
Lorazepam DrugBank
Lormetazepam KEGG DRUG
Methyllorazepam ChemIDplus
N-Methyllorazepam ChemIDplus
O-Chlorooxazepam DrugBank
O-Chloroxazepam ChemIDplus
Brand Name Source
Loramet (TN) KEGG DRUG
Manual Xrefs Databases
1608 DrugCentral
BE621819 Patent
D01657 KEGG DRUG
DB00186 DrugBank
HMDB0041919 HMDB
Lormetazepam Wikipedia
US3296249 Patent
View more database links
Registry Numbers Types Sources
759821 Beilstein Registry Number Beilstein
759821 Reaxys Registry Number Reaxys
848-75-9 CAS Registry Number NIST Chemistry WebBook
848-75-9 CAS Registry Number ChemIDplus
848-75-9 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
11198750 PubMed citation Europe PMC
22792010 PubMed citation Europe PMC
Last Modified
22 February 2017