CHEBI:48391 - cinacalcet hydrochloride

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ChEBI Name cinacalcet hydrochloride
Definition A hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formulae C22H22F3N.HCl
Net Charge 0
Average Mass 393.87267
Monoisotopic Mass 393.14711
InChI InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1
SMILES Cl.C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
Roles Classification
Biological Role(s): P450 inhibitor
An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
Application(s): calcimimetic
A drug that it mimics the action of calcium on tissues.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing cinacalcet hydrochloride (CHEBI:48391) has functional parent cinacalcet (CHEBI:48390)
cinacalcet hydrochloride (CHEBI:48391) has role calcimimetic (CHEBI:48525)
cinacalcet hydrochloride (CHEBI:48391) has role P450 inhibitor (CHEBI:50183)
cinacalcet hydrochloride (CHEBI:48391) is a hydrochloride (CHEBI:36807)
N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride
Synonyms Sources
CNC-HCl Patent
Mimpara ChEBI
Sensipar KEGG DRUG
Brand Name Source
Manual Xrefs Databases
US2007060645 Patent
US2010298606 Patent
WO2010094674 Patent
View more database links
Registry Numbers Types Sources
10219584 Beilstein Registry Number Beilstein
10219584 Reaxys Registry Number Reaxys
364782-34-3 CAS Registry Number ChemIDplus
364782-34-3 CAS Registry Number Patent
Citations Waiting for Citations Types Sources
16200170 PubMed citation Europe PMC
16680561 PubMed citation Europe PMC
17652181 PubMed citation Europe PMC
20555319 PubMed citation Europe PMC
Last Modified
12 July 2011
General Comment
2011-07-12 Cinacalcet acts as a calcimimetic, i.e. it mimics the action of calcium on tissues. The hydrochloride salt is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease who are on haemodialysis or peritoneal dialysis, and for the treatment of hypercalcaemia in patients with parathyroid carcinoma.