CHEBI:4630 - diosmetin

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ChEBI Name diosmetin
ChEBI ID CHEBI:4630
Definition A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C16H12O6
Net Charge 0
Average Mass 300.26288
Monoisotopic Mass 300.063
InChI InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
InChIKey MBNGWHIJMBWFHU-UHFFFAOYSA-N
SMILES COc1ccc(cc1O)-c1cc(=O)c2c(O)cc(O)cc2o1
Metabolite of Species Details
Lepisorus ussuriensis (NCBI:txid699700) Found in whole plant (BTO:0001461). See: PubMed
Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Role(s): plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
tropomyosin-related kinase B receptor agonist
An agonist that binds to and deactivates the tropomyosin-related kinase B (TrkB) receptor, the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing diosmetin (CHEBI:4630) has functional parent luteolin (CHEBI:15864)
diosmetin (CHEBI:4630) has role antineoplastic agent (CHEBI:35610)
diosmetin (CHEBI:4630) has role antioxidant (CHEBI:22586)
diosmetin (CHEBI:4630) has role plant metabolite (CHEBI:76924)
diosmetin (CHEBI:4630) has role tropomyosin-related kinase B receptor agonist (CHEBI:140489)
diosmetin (CHEBI:4630) is a 3'-hydroxyflavonoid (CHEBI:27741)
diosmetin (CHEBI:4630) is a monomethoxyflavone (CHEBI:25401)
diosmetin (CHEBI:4630) is a trihydroxyflavone (CHEBI:27116)
Incoming diosmin (CHEBI:4631) has functional parent diosmetin (CHEBI:4630)
IUPAC Name
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
Synonyms Sources
3',5,7-trihydroxy-4'-methoxyflavone ChEBI
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone ChemIDplus
Diosmetin KEGG COMPOUND
Luteolin 4'-methyl ether KEGG COMPOUND
Salinigricoflavonol HMDB
Database Links Databases
4601 DrugCentral
C00001036 KNApSAcK
C10038 KEGG COMPOUND
Diosmetin Wikipedia
HMDB0029676 HMDB
KR20080049174 Patent
LMPK12110824 LIPID MAPS
US2011201565 Patent
View more database links
Registry Numbers Types Sources
294492 Reaxys Registry Number Reaxys
520-34-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
20635154 PubMed citation Europe PMC
21176927 PubMed citation Europe PMC
21791871 PubMed citation Europe PMC
21851214 PubMed citation Europe PMC
22749133 PubMed citation Europe PMC
Last Modified
27 March 2018