CHEBI:42471 - forskolin

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ChEBI Name forskolin
ChEBI ID CHEBI:42471
Definition A labdane diterpenoid isolated from the Indian Coleus plant.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C22H34O7
Net Charge 0
Average Mass 410.50120
Monoisotopic Mass 410.230
InChI InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChIKey OHCQJHSOBUTRHG-KGGHGJDLSA-N
SMILES [H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
Roles Classification
Biological Role(s): plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
anti-HIV agent
An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
protein kinase A agonist
A protein kinase agonist that selectively binds to and activates a protein kinase A receptor
adenylate cyclase agonist
Any agonist of one or more of the isoforms of adenylate cyclase (EC 4.6.1.1).
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
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ChEBI Ontology
Outgoing forskolin (CHEBI:42471) has role adenylate cyclase agonist (CHEBI:78548)
forskolin (CHEBI:42471) has role anti-HIV agent (CHEBI:64946)
forskolin (CHEBI:42471) has role antihypertensive agent (CHEBI:35674)
forskolin (CHEBI:42471) has role plant metabolite (CHEBI:76924)
forskolin (CHEBI:42471) has role platelet aggregation inhibitor (CHEBI:50427)
forskolin (CHEBI:42471) has role protein kinase A agonist (CHEBI:78547)
forskolin (CHEBI:42471) is a acetate ester (CHEBI:47622)
forskolin (CHEBI:42471) is a cyclic ketone (CHEBI:3992)
forskolin (CHEBI:42471) is a labdane diterpenoid (CHEBI:36770)
forskolin (CHEBI:42471) is a organic heterotricyclic compound (CHEBI:26979)
forskolin (CHEBI:42471) is a triol (CHEBI:27136)
Incoming 1,9-dideoxyforskolin (CHEBI:50295) has functional parent forskolin (CHEBI:42471)
methylpiperazinoforskolin (CHEBI:42430) has functional parent forskolin (CHEBI:42471)
IUPAC Name
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
INNs Sources
colforsin ChemIDplus
colforsina ChemIDplus
colforsine ChemIDplus
colforsinum ChemIDplus
Synonyms Sources
7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one ChemIDplus
Coleonolk KEGG COMPOUND
Colforsin KEGG COMPOUND
FORSKOLIN PDBeChem
Forskolin KEGG COMPOUND
Database Links Databases
C00003416 KNApSAcK
C09076 KEGG COMPOUND
D03584 KEGG DRUG
DB02587 DrugBank
DE2557784 Patent
FOK PDBeChem
Forskolin Wikipedia
US4088659 Patent
US4476140 Patent
View more database links
Registry Numbers Types Sources
4300863 Beilstein Registry Number Beilstein
4300863 Reaxys Registry Number Reaxys
66428-89-5 CAS Registry Number ChemIDplus
66575-29-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
28 July 2014