CHEBI:3763 - clorgyline

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ChEBI Name clorgyline
ChEBI ID CHEBI:3763
Definition An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C13H15Cl2NO
Net Charge 0
Average Mass 272.17000
Monoisotopic Mass 271.053
InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
InChIKey BTFHLQRNAMSNLC-UHFFFAOYSA-N
SMILES CN(CCCOc1ccc(Cl)cc1Cl)CC#C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 1.4.3.4 (monoamine oxidase) inhibitor
An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4).
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
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ChEBI Ontology
Outgoing clorgyline (CHEBI:3763) has role antidepressant (CHEBI:35469)
clorgyline (CHEBI:3763) has role EC 1.4.3.4 (monoamine oxidase) inhibitor (CHEBI:38623)
clorgyline (CHEBI:3763) is a aromatic ether (CHEBI:35618)
clorgyline (CHEBI:3763) is a dichlorobenzene (CHEBI:23697)
clorgyline (CHEBI:3763) is a terminal acetylenic compound (CHEBI:73477)
clorgyline (CHEBI:3763) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
N-[3-(2,4-dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine
INNs Sources
clorgilina ChemIDplus
clorgiline ChemIDplus
clorgiline WHO MedNet
clorgilinum ChemIDplus
Synonyms Sources
M & B 9302 ChemIDplus
M and B 9302 ChemIDplus
M&B 9302 ChemIDplus
N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-2-propynylamine ChemIDplus
N-methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine ChEBI
Manual Xrefs Databases
C11685 KEGG COMPOUND
Clorgiline Wikipedia
CPD-7656 MetaCyc
D03248 KEGG DRUG
DB04017 DrugBank
LSM-5808 LINCS
MLG PDBeChem
View more database links
Registry Numbers Types Sources
17780-72-2 CAS Registry Number ChemIDplus
17780-72-2 CAS Registry Number NIST Chemistry WebBook
1976758 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
21079379 PubMed citation Europe PMC
22203607 PubMed citation Europe PMC
23546802 PubMed citation Europe PMC
5119769 PubMed citation Europe PMC
Last Modified
25 February 2016