CHEBI:3237 - butein

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ChEBI Name butein
ChEBI ID CHEBI:3237
Definition A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C15H12O5
Net Charge 0
Average Mass 272.25280
Monoisotopic Mass 272.068
InChI InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
InChIKey AYMYWHCQALZEGT-ORCRQEGFSA-N
SMILES Oc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1
Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Role(s): tyrosine kinase inhibitor
Any protein kinase inhibitor that interferes with the action of tyrosine kinase.
EC 1.1.1.21 (aldehyde reductase) inhibitor
An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing butein (CHEBI:3237) has role antineoplastic agent (CHEBI:35610)
butein (CHEBI:3237) has role antioxidant (CHEBI:22586)
butein (CHEBI:3237) has role EC 1.1.1.21 (aldehyde reductase) inhibitor (CHEBI:48550)
butein (CHEBI:3237) has role tyrosine kinase inhibitor (CHEBI:38637)
butein (CHEBI:3237) is a chalcones (CHEBI:23086)
IUPAC Names
(2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
Synonyms Sources
(E)-2',3,4,4'-terahydroxychalcone ChEBI
2',3,4,4'-Tetrahydroxychalcone ChemIDplus
3,4,2',4'-Tetrahydroxychalcone ChemIDplus
Butein KEGG COMPOUND
Manual Xrefs Databases
Butein Wikipedia
C00006941 KNApSAcK
C08578 KEGG COMPOUND
LMPK12120111 LIPID MAPS
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Registry Numbers Types Sources
2056928 Reaxys Registry Number Reaxys
487-52-5 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
28 July 2014