buspirone hydrochloride (CHEBI:3224)

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ChEBI Name	buspirone hydrochloride

ChEBI ID	CHEBI:3224

Definition	A hydrochloride salt resulting from the reaction of equimolar amounts of buspirone and hydrogen chloride.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formulae

C21H31N5O2.HCl
C21H32ClN5O2

Net Charge

Average Mass

421.965

Monoisotopic Mass

421.22445

InChI

InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChIKey

RICLFGYGYQXUFH-UHFFFAOYSA-N

SMILES

C=1N=C(N=CC1)N2CCN(CC2)CCCCN3C(CC4(CC3=O)CCCC4)=O.Cl

Roles Classification
Biological Role(s):	EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.

Application(s):	anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.

ChEBI Ontology
Outgoing	buspirone hydrochloride (CHEBI:3224) has part buspirone(1+) (CHEBI:132102) buspirone hydrochloride (CHEBI:3224) has role anxiolytic drug (CHEBI:35474) buspirone hydrochloride (CHEBI:3224) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) buspirone hydrochloride (CHEBI:3224) has role sedative (CHEBI:35717) buspirone hydrochloride (CHEBI:3224) has role serotonergic agonist (CHEBI:35941) buspirone hydrochloride (CHEBI:3224) is a hydrochloride (CHEBI:36807)

IUPAC Name

8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

Synonyms	Sources
1-[4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-4-(pyrimidin-2-yl)piperazin-1-ium chloride	IUPAC
N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-1,1-cyclopentanediacetamide monohydrochloride	ChemIDplus

Brand Name	Source
Buspar	KEGG DRUG

Last Modified

01 June 2016