CHEBI:28777 - liquiritigenin

Main ChEBI Ontology Automatic Xrefs
ChEBI Name liquiritigenin
ChEBI ID CHEBI:28777
Definition A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor β.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:25065, CHEBI:42001, CHEBI:6501
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Formula C15H12O4
Net Charge 0
Average Mass 256.25340
InChI InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
InChIKey FURUXTVZLHCCNA-AWEZNQCLSA-N
SMILES Oc1ccc(cc1)[C@@H]1CC(=O)c2ccc(O)cc2O1
Metabolite of Species Details
Glycyrrhiza glabra (NCBI:49827) See: PubMed
Platymiscium floribundum (NCBI:500185) See: PubMed
Roles Classification
Biological Role(s): hormone agonist
A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
Application(s): hormone agonist
A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
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ChEBI Ontology
Outgoing liquiritigenin (CHEBI:28777) has role hormone agonist (CHEBI:51060)
liquiritigenin (CHEBI:28777) has role plant metabolite (CHEBI:76924)
liquiritigenin (CHEBI:28777) is a dihydroxyflavanone (CHEBI:38749)
Incoming liquiritin (CHEBI:80845) has functional parent liquiritigenin (CHEBI:28777)
IUPAC Name
(2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
Synonyms Sources
(−)-liquiritigenin ChEBI
(2S)-7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one ChemIDplus
(2S)-liquiritigenin ChEMBL
4',7-Dihydroxyflavanone ChemIDplus
7,4'-Dihydroxyflavanone KEGG COMPOUND
7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE PDBeChem
Liquiritigenin KEGG COMPOUND
liquiritigenin UniProt
Database Links Databases
C00000977 KNApSAcK
C09762 KEGG COMPOUND
DFV PDBeChem
HMDB29519 HMDB
Liquiritigenin Wikipedia
LMPK12140061 LIPID MAPS
View more database links
Registry Numbers Types Sources
3593780 Beilstein Registry Number Beilstein
3593780 Reaxys Registry Number Reaxys
578-86-9 CAS Registry Number KEGG COMPOUND
578-86-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
17950610 PubMed citation ChEMBL
18177995 PubMed citation CiteXplore
21866899 PubMed citation CiteXplore
Last Modified
08 June 2015