yoda 1 (CHEBI:194079)

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ChEBI Name	yoda 1

ChEBI ID	CHEBI:194079

Definition	A member of the class of thiadiazoles that is 1,3,4-thiadiazole substituted by pyrazin-2-yl and (2,6-dichlorobenzyl)sulfanediyl groups at positions 2 and 5, respectively. It is a selective activator of mechanosensitive channel piezo1.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Ceri

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Formula

C13H8Cl2N4S2

Net Charge

Average Mass

355.260

Monoisotopic Mass

353.95674

InChI

InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2

InChIKey

BQNXBSYSQXSXPT-UHFFFAOYSA-N

SMILES

ClC1=CC=CC(Cl)=C1CSC1=NN=C(S1)C1=NC=CN=C1

Roles Classification
Biological Role(s):	glycine transporter 2 inhibitor Any glycine transporter inhibitor that interferes with the action of glycine 2 transporters. piezo1 agonist An agonist that binds to and activates piezo1 receptors.

ChEBI Ontology
Outgoing	yoda 1 (CHEBI:194079) has role glycine transporter 2 inhibitor (CHEBI:85424) yoda 1 (CHEBI:194079) has role piezo1 agonist (CHEBI:194154) yoda 1 (CHEBI:194079) is a aromatic compound (CHEBI:33655) yoda 1 (CHEBI:194079) is a dichlorobenzene (CHEBI:23697) yoda 1 (CHEBI:194079) is a organic sulfide (CHEBI:16385) yoda 1 (CHEBI:194079) is a pyrazines (CHEBI:38314) yoda 1 (CHEBI:194079) is a thiadiazoles (CHEBI:38099)

IUPAC Name

2-{5-[(2,6-dichlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}pyrazine

Synonyms	Sources
2-((2,6-dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole	ChemIDplus
2-(5-{[(2,6-dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine	IUPAC
2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine	ChEBI
2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine	ChEBI
GlyT2-IN-1	ChEBI
yoda-1	ChEBI
yoda1	ChEBI

Registry Number	Type	Source
448947-81-7	CAS Registry Number	ChemIDplus

Last Modified

09 December 2022