CHEBI:17160 - 17α-estradiol

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ChEBI Name 17α-estradiol
ChEBI ASCII Name 17alpha-estradiol
Definition An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17α stereoisomer).
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:4862, CHEBI:23961, CHEBI:14217
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Formula C18H24O2
Net Charge 0
Average Mass 272.38196
Monoisotopic Mass 272.17763
InChI InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
SMILES [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21
Roles Classification
Biological Role(s): estrogen
A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
(via estradiol )
human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
(via estradiol )
Application(s): geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing 17α-estradiol (CHEBI:17160) has role estrogen (CHEBI:50114)
17α-estradiol (CHEBI:17160) has role geroprotector (CHEBI:176497)
17α-estradiol (CHEBI:17160) is a 17α-hydroxy steroid (CHEBI:35342)
17α-estradiol (CHEBI:17160) is a 3-hydroxy steroid (CHEBI:36834)
17α-estradiol (CHEBI:17160) is a estradiol (CHEBI:23965)
Incoming 17α-(N-acetyl-α-D-glucosaminyl)estradiol 3-glucuronoside (CHEBI:73201) has functional parent 17α-estradiol (CHEBI:17160)
17α-(N-acetyl-D-glucosaminyl)estradiol 3-glucosiduronic acid (CHEBI:16129) has functional parent 17α-estradiol (CHEBI:17160)
17α-estradiol 17-O-(β-D-glucuronide) (CHEBI:137490) has functional parent 17α-estradiol (CHEBI:17160)
17α-estradiol 3-glucosiduronic acid (CHEBI:15822) has functional parent 17α-estradiol (CHEBI:17160)
INNs Sources
alfatradiol WHO MedNet
alfatradiol WHO MedNet
alfatradiol WHO MedNet
alfatradiolum WHO MedNet
Synonyms Sources
(17α)-estra-1,3,5(10)-triene-3,17-diol ChEBI
1,3,5-estratriene-3,17α-diol ChEBI
13β-methyl-1,3,5(10)-gonatriene-3,17α-diol HMDB
17-epiestradiol HMDB
17alpha-Estradiol KEGG COMPOUND
17α-estradiol UniProt
17α-oestradiol ChEBI
3,17α-dihydroxyestra-1,3,5(10)-triene HMDB
3,17α-dihydroxyoestra-1,3,5(10)-triene ChEBI
α-estradiol ChemIDplus
epiestradiol ChemIDplus
epiestrol HMDB
estra-1,3,5(10)-triene-3,17α-diol ChEBI
estra-1,3,5(10)trien-3,17alpha-diol ChEBI
Estradiol-17alpha KEGG COMPOUND
oestra-1,3,5(10)-triene-3,17α-diol HMDB
Manual Xrefs Databases
17%CE%B1-Estradiol Wikipedia
61840 ChemSpider
CPD-351 MetaCyc
FDB011524 FooDB
HMDB0000429 HMDB
View more database links
Registry Numbers Types Sources
2190991 Gmelin Registry Number Gmelin
2698044 Beilstein Registry Number ChemIDplus
57-91-0 CAS Registry Number KEGG COMPOUND
57-91-0 CAS Registry Number ChemIDplus
57-91-0 CAS Registry Number NIST Chemistry WebBook
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Last Modified
23 September 2021