CHEBI:17158 - methylglyoxal

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ChEBI Name methylglyoxal
Definition A 2-oxo aldehyde derived from propanal.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:6875, CHEBI:11643, CHEBI:14599, CHEBI:25303
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Formula C3H4O2
Net Charge 0
Average Mass 72.06266
InChI InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3
Metabolite of Species Details
Homo sapiens (NCBI:9606) See: DOI
Roles Classification
Biological Role(s): human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
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ChEBI Ontology
Outgoing methylglyoxal (CHEBI:17158) has role human metabolite (CHEBI:77746)
methylglyoxal (CHEBI:17158) is a 2-oxo aldehyde (CHEBI:27659)
methylglyoxal (CHEBI:17158) is a propanals (CHEBI:26282)
Incoming mitoguazone (CHEBI:43996) has functional parent methylglyoxal (CHEBI:17158)
Synonyms Sources
1,2-propanedione NIST Chemistry WebBook
2-Ketopropionaldehyde KEGG COMPOUND
2-Oxopropanal KEGG COMPOUND
2-oxopropionaldehyde ChemIDplus
acetylformaldehyde ChemIDplus
acetylformyl NIST Chemistry WebBook
α-ketopropionaldehyde NIST Chemistry WebBook
CH3COCHO NIST Chemistry WebBook
Methylglyoxal KEGG COMPOUND
methylglyoxal UniProt
Pyruvaldehyde KEGG COMPOUND
Pyruvic aldehyde KEGG COMPOUND
Database Links Databases
C00007562 KNApSAcK
Methylglyoxal Wikipedia
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Registry Numbers Types Sources
78-98-8 CAS Registry Number ChemIDplus
78-98-8 CAS Registry Number NIST Chemistry WebBook
906750 Beilstein Registry Number Beilstein
906750 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10373458 PubMed citation CiteXplore
10723098 PubMed citation CiteXplore
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15520007 PubMed citation CiteXplore
17103372 PubMed citation CiteXplore
19202315 PubMed citation CiteXplore
20096340 PubMed citation CiteXplore
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24168114 PubMed citation CiteXplore
9506998 PubMed citation CiteXplore
Last Modified
23 October 2015
General Comment
2011-01-26 Formed endogenously in numerous reactions, it modifies Arg and Lys residues in proteins, forming advanced glycation end-products which are associated with complications of diabetes and some neurodegenerative diseases.