CHEBI:149601 - bempedoic acid

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ChEBI Name bempedoic acid
ChEBI ID CHEBI:149601
Definition An α,ω-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C19H36O5
Net Charge 0
Average Mass 344.492
Monoisotopic Mass 344.25627
InChI InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
InChIKey HYHMLYSLQUKXKP-UHFFFAOYSA-N
SMILES C(C(CCCCCC(CCCCCC(C(O)=O)(C)C)O)(C)C)(O)=O
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): EC 2.3.3.8 (ATP citrate synthase) inhibitor
An EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor that interferes with the action of ATP citrate synthase (EC 2.3.3.8).
Application(s): antilipemic drug
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
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ChEBI Ontology
Outgoing bempedoic acid (CHEBI:149601) has role antilipemic drug (CHEBI:35679)
bempedoic acid (CHEBI:149601) has role EC 2.3.3.8 (ATP citrate synthase) inhibitor (CHEBI:149598)
bempedoic acid (CHEBI:149601) has role prodrug (CHEBI:50266)
bempedoic acid (CHEBI:149601) is a α,ω-dicarboxylic acid (CHEBI:28383)
IUPAC Name
8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
INNs Sources
acide bempédoïque WHO MedNet
ácido bempedoico WHO MedNet
acidum bempedoicum WHO MedNet
bempedoic acid WHO MedNet
Synonyms Sources
ESP 55016 ChemIDplus
ESP-55016 ChemIDplus
ETC 1002 ChemIDplus
ETC-1002 ChemIDplus
ETC1002 ChemIDplus
Brand Name Source
Nexletol KEGG DRUG
Manual Xrefs Databases
Bempedoic_acid Wikipedia
D10691 KEGG DRUG
DB11936 DrugBank
View more database links
Registry Number Type Source
738606-46-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
27 April 2020