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> Main
CHEBI:134687 - naltrexone hydrochloride
Main
ChEBI Ontology
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ChEBI Name
naltrexone hydrochloride
ChEBI ID
CHEBI:134687
Definition
A hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a μ-opioid receptor antagonist that is used to treat alcohol dependence.
Stars
This entity has been manually annotated by the ChEBI Team.
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Read full article at Wikipedia
Formula
C20H24ClNO4
Net Charge
0
Average Mass
377.863
Monoisotopic Mass
377.13939
InChI
InChI=1S/C20H23NO4.ClH/c22-
13-
4-
3-
12-
9-
15-
20(24)
6-
5-
14(23)
18-
19(20,16(12)
17(13)
25-
18)
7-
8-
21(15)
10-
11-
1-
2-
11;/h3-
4,11,15,18,22,24H,1-
2,5-
10H2;1H/t15-
,18+,19+,20-
;/m1./s1
InChIKey
RHBRMCOKKKZVRY-ITLPAZOVSA-N
SMILES
C1=2C[C@@H]3[C@@]4(CCC([C@H]5[C@@]4(C1=C(C(=CC2)O)O5)CCN3CC6CC6)=O)O.Cl
Roles Classification
Biological Role
(s):
mu-opioid receptor antagonist
Any compound that exhibits antagonist activity at the
mu
-opioid receptor
Application
(s):
mu-opioid receptor antagonist
Any compound that exhibits antagonist activity at the
mu
-opioid receptor
antidote to opioid poisoning
A role borne by a molecule that acts to counteract or neutralise the deleterious effects of opioids.
central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
naltrexone hydrochloride (
CHEBI:134687
)
has part
naltrexone(1+) (
CHEBI:134688
)
naltrexone hydrochloride (
CHEBI:134687
)
has role
μ-opioid receptor antagonist (
CHEBI:50137
)
naltrexone hydrochloride (
CHEBI:134687
)
has role
antidote to opioid poisoning (
CHEBI:90755
)
naltrexone hydrochloride (
CHEBI:134687
)
has role
central nervous system depressant (
CHEBI:35488
)
naltrexone hydrochloride (
CHEBI:134687
)
is a
hydrochloride (
CHEBI:36807
)
Incoming
Troxyca ER (
CHEBI:134679
)
has part
naltrexone hydrochloride (
CHEBI:134687
)
IUPAC Names
(5α,17
R
)-17-(cyclopropylmethyl)-3,14-dihydroxy-6-oxo-4,5-epoxymorphinan-17-ium chloride
17-(cyclopropylmethyl)-3,14-dihydroxy-4,5α-epoxymorphinan-6-one hydrochloride
Synonyms
Sources
17-(Cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-one hydrochloride
ChemIDplus
N-Cyclopropylmethyl-noroxymorphone hydrochloride
ChemIDplus
naltrexone monohydrochloride
ChEBI
naltrexone.HCl
ChEBI
Manual Xrefs
Databases
D02095
KEGG DRUG
DB00704
DrugBank
Naltrexone
Wikipedia
View more database links
Registry Numbers
Types
Sources
16676-29-2
CAS Registry Number
ChemIDplus
3580333
Reaxys Registry Number
Reaxys
Citations
Types
Sources
20949341
PubMed citation
Europe PMC
22528547
PubMed citation
Europe PMC
22595640
PubMed citation
Europe PMC
22616317
PubMed citation
Europe PMC
22759074
PubMed citation
Europe PMC
22941847
PubMed citation
Europe PMC
23227366
PubMed citation
Europe PMC
23745947
PubMed citation
Europe PMC
24090623
PubMed citation
Europe PMC
24234803
PubMed citation
Europe PMC
25445974
PubMed citation
Europe PMC
25655411
PubMed citation
Europe PMC
26185466
PubMed citation
Europe PMC
26309861
PubMed citation
Europe PMC
26695349
PubMed citation
Europe PMC
26773883
PubMed citation
Europe PMC
27137146
PubMed citation
Europe PMC
27211522
PubMed citation
Europe PMC
27440072
PubMed citation
Europe PMC
27525968
PubMed citation
Europe PMC
27627782
PubMed citation
Europe PMC
Last Modified
22 February 2017