crisaborole (CHEBI:134677)

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ChEBI Name	crisaborole

ChEBI ID	CHEBI:134677

Definition	A member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C14H10BNO3

Net Charge

Average Mass

251.046

Monoisotopic Mass

251.07537

InChI

InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2

InChIKey

USZAGAREISWJDP-UHFFFAOYSA-N

SMILES

C1=C(C=C2C(=C1)B(OC2)O)OC3=CC=C(C=C3)C#N

Roles Classification
Biological Role(s):	phosphodiesterase IV inhibitor An EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor that specifically blocks the action of phosphodiesterase IV.

Application(s):	antipsoriatic A drug used to treat psoriasis. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.

ChEBI Ontology
Outgoing	crisaborole (CHEBI:134677) has role antipsoriatic (CHEBI:50748) crisaborole (CHEBI:134677) has role non-steroidal anti-inflammatory drug (CHEBI:35475) crisaborole (CHEBI:134677) has role phosphodiesterase IV inhibitor (CHEBI:68844) crisaborole (CHEBI:134677) is a aromatic ether (CHEBI:35618) crisaborole (CHEBI:134677) is a benzoxaborole (CHEBI:78240) crisaborole (CHEBI:134677) is a nitrile (CHEBI:18379)

IUPAC Name

4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile

INN	Source
crisaborole	KEGG DRUG

Synonyms	Sources
AN 2728	ChemIDplus
AN-2728	ChemIDplus
AN2728	ChEBI
Crisaborole topical ointment 2%	ChemIDplus

Brand Name	Source
Eucrisa	ChemIDplus

Last Modified

22 February 2017