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> Main
CHEBI:2639 - amiloride
Main
ChEBI Ontology
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ChEBI Name
amiloride
ChEBI ID
CHEBI:2639
Definition
A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Stars
This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs
CHEBI:47210
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Wikipedia
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Read full article at Wikipedia
Formula
C6H8ClN7O
Net Charge
0
Average Mass
229.62700
Monoisotopic Mass
229.04789
InChI
InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
InChIKey
XSDQTOBWRPYKKA-UHFFFAOYSA-N
SMILES
NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Roles Classification
Chemical Role
(s):
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Br
o
nsted acid).
(via
organic amino compound
)
Biological Role
(s):
sodium channel blocker
An agent that inhibits sodium influx through cell membranes.
Application
(s):
diuretic
An agent that promotes the excretion of urine through its effects on kidney function.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
amiloride (
CHEBI:2639
)
has role
diuretic (
CHEBI:35498
)
amiloride (
CHEBI:2639
)
has role
sodium channel blocker (
CHEBI:38633
)
amiloride (
CHEBI:2639
)
is a
aromatic amine (
CHEBI:33860
)
amiloride (
CHEBI:2639
)
is a
guanidines (
CHEBI:24436
)
amiloride (
CHEBI:2639
)
is a
organochlorine compound (
CHEBI:36683
)
amiloride (
CHEBI:2639
)
is a
pyrazines (
CHEBI:38314
)
amiloride (
CHEBI:2639
)
is conjugate base of
amiloride(1+) (
CHEBI:84745
)
Incoming
5-(
N
,
N
-hexamethylene)amiloride (
CHEBI:76400
)
has functional parent
amiloride (
CHEBI:2639
)
5-(
N
-methyl-
N
-propyl)amiloride (
CHEBI:138016
)
has functional parent
amiloride (
CHEBI:2639
)
ethylisopropylamiloride (
CHEBI:136538
)
has functional parent
amiloride (
CHEBI:2639
)
amiloride(1+) (
CHEBI:84745
)
is conjugate acid of
amiloride (
CHEBI:2639
)
IUPAC Name
3,5-diamino-
N
-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
INNs
Sources
amilorida
ChemIDplus
amiloride
WHO MedNet
amiloride
ChEBI
amiloridum
ChemIDplus
Synonyms
Sources
3,5-diamino-
N
-carbamimidoyl-6-chloropyrazine-2-carboxamide
IUPAC
Amiloride
KEGG COMPOUND
N
-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
ChemIDplus
Manual Xrefs
Databases
158
DrugCentral
Amiloride
Wikipedia
AMR
PDBeChem
BE639386
Patent
C06821
KEGG COMPOUND
CPD-10324
MetaCyc
D07447
KEGG DRUG
DB00594
DrugBank
HMDB0014732
HMDB
LSM-4194
LINCS
US3313813
Patent
View more database links
Registry Numbers
Types
Sources
2609-46-3
CAS Registry Number
ChemIDplus
616612
Beilstein Registry Number
Beilstein
657410
Reaxys Registry Number
Reaxys
Citations
Types
Sources
16020936
PubMed citation
Europe PMC
24410943
PubMed citation
Europe PMC
24419567
PubMed citation
Europe PMC
9124403
PubMed citation
Europe PMC
Last Modified
26 July 2017