alpha-naphthoflavone (CHEBI:76995)

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ChEBI Name	α-naphthoflavone

ChEBI ID	CHEBI:76995

ChEBI ASCII Name	alpha-naphthoflavone

Definition	An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C19H12O2

Net Charge

Average Mass

272.29740

Monoisotopic Mass

272.08373

InChI

InChI=1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H

InChIKey

VFMMPHCGEFXGIP-UHFFFAOYSA-N

SMILES

O=c1cc(oc2c3ccccc3ccc12)-c1ccccc1

Roles Classification
Biological Role(s):	EC 1.14.14.14 (aromatase) inhibitor An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor which interferes with the action of aromatase (EC 1.14.14.14) and so reduces production of estrogenic steroid hormones. aryl hydrocarbon receptor antagonist An antagonist that binds to and activates aryl hydrocarbon receptors (AhRs). aryl hydrocarbon receptor agonist An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).

ChEBI Ontology
Outgoing	α-naphthoflavone (CHEBI:76995) has role aryl hydrocarbon receptor agonist (CHEBI:72768) α-naphthoflavone (CHEBI:76995) has role aryl hydrocarbon receptor antagonist (CHEBI:76998) α-naphthoflavone (CHEBI:76995) has role EC 1.14.14.14 (aromatase) inhibitor (CHEBI:50790) α-naphthoflavone (CHEBI:76995) is a extended flavonoid (CHEBI:71037) α-naphthoflavone (CHEBI:76995) is a naphtho-γ-pyrone (CHEBI:64542) α-naphthoflavone (CHEBI:76995) is a organic heterotricyclic compound (CHEBI:26979)

IUPAC Name

2-phenyl-4H-benzo[h]chromen-4-one

Last Modified

09 March 2020