telbivudine (CHEBI:63624)

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ChEBI Name	telbivudine

ChEBI ID	CHEBI:63624

Definition	A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Anonymous

Supplier Information

Download	Molfile XML SDF

Wikipedia	License

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Formula

C10H14N2O5

Net Charge

Average Mass

242.22860

Monoisotopic Mass

242.09027

InChI

InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1

InChIKey

IQFYYKKMVGJFEH-CSMHCCOUSA-N

SMILES

Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O

Roles Classification
Biological Role(s):	antiviral drug A substance used in the prophylaxis or therapy of virus diseases. EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce.

Application(s):	antiviral drug A substance used in the prophylaxis or therapy of virus diseases.

ChEBI Ontology
Outgoing	telbivudine (CHEBI:63624) has functional parent thymine (CHEBI:17821) telbivudine (CHEBI:63624) has role antiviral drug (CHEBI:36044) telbivudine (CHEBI:63624) has role EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor (CHEBI:59897) telbivudine (CHEBI:63624) is a pyrimidine 2'-deoxyribonucleoside (CHEBI:19255) telbivudine (CHEBI:63624) is enantiomer of thymidine (CHEBI:17748)

Incoming	thymidine (CHEBI:17748) is enantiomer of telbivudine (CHEBI:63624)

IUPAC Name

1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione

INN	Source
telbivudine	KEGG DRUG

Synonyms	Sources
1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil	ChEBI
2'-Deoxy-L-thymidine	DrugBank
β-L-2'-deoxythymidine	ChEBI
Beta-l-thymidine	DrugBank
Epavudine	DrugBank
L-deoxythymidine	DrugBank
L-DT	DrugBank
L-thymidine	DrugBank
LDT	DrugBank

Last Modified

22 February 2017