pomalidomide (CHEBI:72690)

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ChEBI Name	pomalidomide

ChEBI ID	CHEBI:72690

Definition	An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C13H11N3O4

Net Charge

Average Mass

273.24410

Monoisotopic Mass

273.07496

InChI

InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChIKey

UVSMNLNDYGZFPF-UHFFFAOYSA-N

SMILES

Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system.

Application(s):	angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system.

ChEBI Ontology
Outgoing	pomalidomide (CHEBI:72690) has functional parent thalidomide (CHEBI:9513) pomalidomide (CHEBI:72690) has role angiogenesis inhibitor (CHEBI:48422) pomalidomide (CHEBI:72690) has role antineoplastic agent (CHEBI:35610) pomalidomide (CHEBI:72690) has role immunomodulator (CHEBI:50846) pomalidomide (CHEBI:72690) is a aromatic amine (CHEBI:33860) pomalidomide (CHEBI:72690) is a dicarboximide (CHEBI:35356) pomalidomide (CHEBI:72690) is a isoindoles (CHEBI:24897) pomalidomide (CHEBI:72690) is a piperidones (CHEBI:48589)

IUPAC Name

4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione

INN	Source
pomalidomide	KEGG DRUG

Synonyms	Sources
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide	ChemIDplus
4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione	ChemIDplus
4-Aminothalidomide	ChemIDplus
CC 4047	ChemIDplus
CC-4047	ChemIDplus

Brand Name	Source
Pomalyst	ChemIDplus

Last Modified

22 February 2017