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InChI=1S/CH4O/c1-2/h2H,1H3
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ChEBI
> Main
CHEBI:38940 - sunitinib
Main
ChEBI Ontology
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ChEBI Name
sunitinib
ChEBI ID
CHEBI:38940
Stars
This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Molfile
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Formula
C22H27FN4O2
Net Charge
0
Average Mass
398.47380
Monoisotopic Mass
398.21180
InChI
InChI=1S/C22H27FN4O2/c1-
5-
27(6-
2)
10-
9-
24-
22(29)
20-
13(3)
19(25-
14(20)
4)
12-
17-
16-
11-
15(23)
7-
8-
18(16)
26-
21(17)
28/h7-
8,11-
12,25H,5-
6,9-
10H2,1-
4H3,(H,24,29)
(H,26,28)
/b17-
12-
InChIKey
WINHZLLDWRZWRT-ATVHPVEESA-N
SMILES
CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Roles Classification
Biological Role
(s):
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
vascular endothelial growth factor receptor antagonist
An antagonist at the vascular endothelial growth factor receptor.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
Application
(s):
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
immunomodulator
Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing
sunitinib (
CHEBI:38940
)
has functional parent
3-methyleneoxindole (
CHEBI:17920
)
sunitinib (
CHEBI:38940
)
has role
angiogenesis inhibitor (
CHEBI:48422
)
sunitinib (
CHEBI:38940
)
has role
antineoplastic agent (
CHEBI:35610
)
sunitinib (
CHEBI:38940
)
has role
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (
CHEBI:62434
)
sunitinib (
CHEBI:38940
)
has role
immunomodulator (
CHEBI:50846
)
sunitinib (
CHEBI:38940
)
has role
neuroprotective agent (
CHEBI:63726
)
sunitinib (
CHEBI:38940
)
has role
vascular endothelial growth factor receptor antagonist (
CHEBI:65207
)
sunitinib (
CHEBI:38940
)
is a
monocarboxylic acid amide (
CHEBI:29347
)
sunitinib (
CHEBI:38940
)
is a
pyrroles (
CHEBI:26455
)
Incoming
linkable sunitinib analogue (
CHEBI:39081
)
has functional parent
sunitinib (
CHEBI:38940
)
IUPAC Name
N
-
[2-
(diethylamino)ethyl]-
5-
[(
Z
)-
(5-
fluoro-
2-
oxo-
1,2-
dihydro-
3
H
-
indol-
3-
ylidene)methyl]-
2,4-
dimethyl-
1
H
-
pyrrole-
3-
carboxamide
INNs
Sources
sunitinib
ChEBI
sunitinibum
ChEBI
Synonyms
Sources
SU-11248
ChEBI
Sunitinib
ChemIDplus
Sutent
ChemIDplus
Manual Xrefs
Databases
2544
DrugCentral
DB01268
DrugBank
HMDB0015397
HMDB
Sunitinib
Wikipedia
View more database links
Registry Number
Type
Source
557795-19-4
CAS Registry Number
ChemIDplus
Citations
Types
Sources
12531805
PubMed citation
Europe PMC
16845442
PubMed citation
Europe PMC
16916320
PubMed citation
Europe PMC
17327610
PubMed citation
Europe PMC
17962201
PubMed citation
Europe PMC
18971320
PubMed citation
Europe PMC
19830602
PubMed citation
Europe PMC
20406969
PubMed citation
Europe PMC
21792888
PubMed citation
Europe PMC
24188025
PubMed citation
Europe PMC
24393200
PubMed citation
Europe PMC
24402960
PubMed citation
Europe PMC
24403097
PubMed citation
Europe PMC
24521256
PubMed citation
Europe PMC
Last Modified
22 February 2017