CHEBI:87635 - statin (synthetic)

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ChEBI Name statin (synthetic)
Definition A statin which does not occur naturally and which is not obtained by chemical transformation of a naturally occurring statin.
Stars This entity has been manually annotated by the ChEBI Team.
Roles Classification
Biological Role(s): EC (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC for the NADPH-dependent enzyme and EC for an NADH-dependent enzyme.
(via statin )
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
(via statin )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing statin (synthetic) (CHEBI:87635) is a statin (CHEBI:87631)
Incoming (3R,5S)-fluvastatin (CHEBI:38565) is a statin (synthetic) (CHEBI:87635)
(3R,5S)-fluvastatin sodium (CHEBI:77602) is a statin (synthetic) (CHEBI:87635)
(3S,5R)-fluvastatin (CHEBI:5136) is a statin (synthetic) (CHEBI:87635)
(3S,5R)-fluvastatin sodium (CHEBI:77603) is a statin (synthetic) (CHEBI:87635)
atorvastatin (CHEBI:39548) is a statin (synthetic) (CHEBI:87635)
atorvastatin calcium trihydrate (CHEBI:2911) is a statin (synthetic) (CHEBI:87635)
cerivastatin (CHEBI:3558) is a statin (synthetic) (CHEBI:87635)
cerivastatin sodium (CHEBI:3559) is a statin (synthetic) (CHEBI:87635)
fluvastatin (CHEBI:38561) is a statin (synthetic) (CHEBI:87635)
fluvastatin sodium (CHEBI:5137) is a statin (synthetic) (CHEBI:87635)
pitavastatin (CHEBI:32020) is a statin (synthetic) (CHEBI:87635)
pitavastatin calcium (CHEBI:71258) is a statin (synthetic) (CHEBI:87635)
rosuvastatin (CHEBI:38545) is a statin (synthetic) (CHEBI:87635)
Synonyms Sources
statins (synthetic) ChEBI
synthetic statin ChEBI
synthetic statins ChEBI
Citations Waiting for Citations Types Sources
11464449 PubMed citation Europe PMC
1464741 PubMed citation Europe PMC
16059807 PubMed citation Europe PMC
20467214 PubMed citation Europe PMC
Last Modified
24 August 2015