CHEBI:87633 - statin (semi-synthetic)

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ChEBI Name statin (semi-synthetic)
Definition A statin that is derived from a naturally occurring statin by partial chemical synthesis.
Stars This entity has been manually annotated by the ChEBI Team.
Roles Classification
Biological Role(s): EC (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC for the NADPH-dependent enzyme and EC for an NADH-dependent enzyme.
(via statin )
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
(via statin )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing statin (semi-synthetic) (CHEBI:87633) is a semisynthetic derivative (CHEBI:72588)
statin (semi-synthetic) (CHEBI:87633) is a statin (CHEBI:87631)
Incoming pravastatin (CHEBI:63618) is a statin (semi-synthetic) (CHEBI:87633)
pravastatin sodium (CHEBI:8361) is a statin (semi-synthetic) (CHEBI:87633)
simvastatin (CHEBI:9150) is a statin (semi-synthetic) (CHEBI:87633)
Synonyms Sources
semi-synthetic statin ChEBI
semi-synthetic statins ChEBI
statins (semi-synthetic) ChEBI
Citations Waiting for Citations Types Sources
1464741 PubMed citation Europe PMC
20467214 PubMed citation Europe PMC
Last Modified
24 August 2015