CHEBI:87632 - statin (naturally occurring)

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ChEBI Name statin (naturally occurring)
Definition Any statin that occurs in nature. The class includes compactin (also known as mevastatin), isolated from a fermentation broth of Penicillium citrinum, and lovastatin, isolated from Aspergillus terreus.
Stars This entity has been manually annotated by the ChEBI Team.
Roles Classification
Biological Role(s): metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
EC (hydroxymethylglutaryl-CoA reductase) inhibitor
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC for the NADPH-dependent enzyme and EC for an NADH-dependent enzyme.
(via statin )
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
(via statin )
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ChEBI Ontology
Outgoing statin (naturally occurring) (CHEBI:87632) has role metabolite (CHEBI:25212)
statin (naturally occurring) (CHEBI:87632) is a statin (CHEBI:87631)
Incoming lovastatin (CHEBI:40303) is a statin (naturally occurring) (CHEBI:87632)
mevastatin (CHEBI:34848) is a statin (naturally occurring) (CHEBI:87632)
Synonyms Sources
naturally occurring statin ChEBI
naturally occurring statins ChEBI
statins (naturally occurring) ChEBI
Manual Xref Database
WO9832751 Patent
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Citations Waiting for Citations Types Sources
1464741 PubMed citation Europe PMC
20467214 PubMed citation Europe PMC
21697731 PubMed citation Europe PMC
22060290 PubMed citation Europe PMC
22302254 PubMed citation Europe PMC
Last Modified
24 August 2015