triprolidine (CHEBI:84116)

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ChEBI Name	triprolidine

ChEBI ID	CHEBI:84116

Definition	An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C19H22N2

Net Charge

Average Mass

278.39140

Monoisotopic Mass

278.17830

InChI

InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+

InChIKey

CBEQULMOCCWAQT-WOJGMQOQSA-N

SMILES

Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.

Application(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.

ChEBI Ontology
Outgoing	triprolidine (CHEBI:84116) has role H₁-receptor antagonist (CHEBI:37955) triprolidine (CHEBI:84116) is a N-alkylpyrrolidine (CHEBI:46775) triprolidine (CHEBI:84116) is a olefinic compound (CHEBI:78840) triprolidine (CHEBI:84116) is a pyridines (CHEBI:26421) triprolidine (CHEBI:84116) is conjugate base of triprolidine(1+) (CHEBI:84117)

Incoming	triprolidine(1+) (CHEBI:84117) is conjugate acid of triprolidine (CHEBI:84116)

IUPAC Name

2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine

Synonyms	Sources
(E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine	NIST Chemistry WebBook
trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene	ChemIDplus
trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene	ChemIDplus
trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine	ChemIDplus

Last Modified

22 February 2017