G-573 (CHEBI:83404)

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ChEBI Name	G-573

ChEBI ID	CHEBI:83404

Definition	A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]furo[3,2-c]pyridine-2-carboxylic acid with the amino group of (2S)-1-(aminooxy)propan-2-ol.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Margaret Duesbury

Supplier Information

Download	Molfile XML SDF

Formula

C17H14F2IN3O4

Net Charge

Average Mass

489.21200

Monoisotopic Mass

488.99971

InChI

InChI=1S/C17H14F2IN3O4/c1-8(24)7-26-23-17(25)16-14(10-5-21-6-12(19)15(10)27-16)22-13-3-2-9(20)4-11(13)18/h2-6,8,22,24H,7H2,1H3,(H,23,25)/t8-/m0/s1

InChIKey

ZEZHPEIEEFTILY-QMMMGPOBSA-N

SMILES

C[C@H](O)CONC(=O)c1oc2c(F)cncc2c1Nc1ccc(I)cc1F

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	G-573 (CHEBI:83404) has role antineoplastic agent (CHEBI:35610) G-573 (CHEBI:83404) has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor (CHEBI:79091) G-573 (CHEBI:83404) is a aromatic amine (CHEBI:33860) G-573 (CHEBI:83404) is a furopyridine (CHEBI:38197) G-573 (CHEBI:83404) is a monocarboxylic acid amide (CHEBI:29347) G-573 (CHEBI:83404) is a organofluorine compound (CHEBI:37143) G-573 (CHEBI:83404) is a organoiodine compound (CHEBI:37142) G-573 (CHEBI:83404) is a secondary alcohol (CHEBI:35681) G-573 (CHEBI:83404) is a secondary amino compound (CHEBI:50995)

IUPAC Name

7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-[(2S)-2-hydroxypropoxy]furo[3,2-c]pyridine-2-carboxamide

Registry Number	Type	Source
13101316	Reaxys Registry Number	Reaxys

Last Modified

09 January 2015