CHEBI:65802 - diuvaretin

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name diuvaretin
ChEBI ID CHEBI:65802
Definition A member of the class of dihydrochalcones that is dihydrochalcone substituted by 2-hydroxybenzyl groups at positions 3 and 5, hydroxy groups at positions 2 and 4 and a methoxy group at position 6. Isolated from the roots of Uvaria acuminata and Uvaria chamae, it exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C30H28O6
Net Charge 0
Average Mass 484.53970
Monoisotopic Mass 484.18859
InChI InChI=1S/C30H28O6/c1-36-30-23(18-21-12-6-8-14-25(21)32)28(34)22(17-20-11-5-7-13-24(20)31)29(35)27(30)26(33)16-15-19-9-3-2-4-10-19/h2-14,31-32,34-35H,15-18H2,1H3
InChIKey KDEMELRYKGOXDL-UHFFFAOYSA-N
SMILES COc1c(Cc2ccccc2O)c(O)c(Cc2ccccc2O)c(O)c1C(=O)CCc1ccccc1
Metabolite of Species Details
Uvaria chamae (NCBI:txid174970) Found in root (BTO:0001188). See: PubMed
Uvaria acuminata (NCBI:txid672960) Found in root (BTO:0001188). See: PubMed
Uvaria leptocladon (NCBI:txid673191) Found in root (BTO:0001188). Previous component: root bark; See: DOI
Roles Classification
Biological Role(s): antimalarial
A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Application(s): antimalarial
A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing diuvaretin (CHEBI:65802) has role antimalarial (CHEBI:38068)
diuvaretin (CHEBI:65802) has role antineoplastic agent (CHEBI:35610)
diuvaretin (CHEBI:65802) has role metabolite (CHEBI:25212)
diuvaretin (CHEBI:65802) is a dihydrochalcones (CHEBI:71230)
diuvaretin (CHEBI:65802) is a monomethoxybenzene (CHEBI:25235)
diuvaretin (CHEBI:65802) is a resorcinols (CHEBI:33572)
IUPAC Name
1-[2,4-dihydroxy-3,5-bis(2-hydroxybenzyl)-6-methoxyphenyl]-3-phenylpropan-1-one
Manual Xref Database
LMPK12120472 LIPID MAPS
View more database links
Registry Number Type Source
2029684 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
12168763 PubMed citation Europe PMC
14709883 PubMed citation Europe PMC
15635168 PubMed citation Europe PMC
1775574 PubMed citation Europe PMC
845713 PubMed citation Europe PMC
Last Modified
14 January 2013