CHEBI:137693 - rhosin

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ChEBI Name rhosin
ChEBI ID CHEBI:137693
Definition A D-tryptophan derivative obtained by formal condensation of the carboxy group of D-tryptophan with the amino group of (quinoxalin-6-yl)methylidenehydrazide. It directly targets the Rho GEF binding domain, thereby preventing Rho from interacting with its GEFs
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Sabrina Toro
Supplier Information
Download Molfile XML SDF
Formula C20H18N6O
Net Charge 0
Average Mass 358.397
Monoisotopic Mass 358.15421
InChI InChI=1S/C20H18N6O/c21-16(10-14-12-24-17-4-2-1-3-15(14)17)20(27)26-25-11-13-5-6-18-19(9-13)23-8-7-22-18/h1-9,11-12,16,24H,10,21H2,(H,26,27)/b25-11+/t16-/m1/s1
InChIKey FGYHLIHEFHCMPP-FVWOBLMASA-N
SMILES C1(=CNC2=C1C=CC=C2)C[C@H](C(=O)N\N=C\C=3C=CC4=C(C3)N=CC=N4)N
Roles Classification
Biological Role(s): RhoA inhibitor
Any inhibitor that interferes with the action of the protein RhoA.
RhoC inhibitor
Any inhibitor that interferes with the action of the protein RhoC.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing rhosin (CHEBI:137693) has role antineoplastic agent (CHEBI:35610)
rhosin (CHEBI:137693) has role RhoA inhibitor (CHEBI:138380)
rhosin (CHEBI:137693) has role RhoC inhibitor (CHEBI:138381)
rhosin (CHEBI:137693) is a D-tryptophan derivative (CHEBI:47997)
rhosin (CHEBI:137693) is a hydrazone (CHEBI:38532)
rhosin (CHEBI:137693) is a quinoxaline derivative (CHEBI:38771)
IUPAC Name
(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(quinoxalin-6-yl)methylidene]propanehydrazide
Synonyms Sources
(quinoxalinylmethylidene-D-tryptophanyl)hydrazide ChEBI
D-tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide ChEBI
Rho Inhibitor SUBMITTER
Registry Number Type Source
25133391 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
22726684 PubMed citation Europe PMC
23382194 PubMed citation Europe PMC
26482039 PubMed citation Europe PMC
27187066 PubMed citation Europe PMC
27681226 PubMed citation Europe PMC
28411215 PubMed citation Europe PMC
Last Modified
05 September 2017