CHEBI:8466 - propafenone hydrochloride

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ChEBI Name propafenone hydrochloride
ChEBI ID CHEBI:8466
Definition A hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formulae C21H27NO3.HCl
C21H28ClNO3
Net Charge 0
Average Mass 377.90500
Monoisotopic Mass 377.17577
InChI InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
InChIKey XWIHRGFIPXWGEF-UHFFFAOYSA-N
SMILES Cl.CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1
Roles Classification
Application(s): anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
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ChEBI Ontology
Outgoing propafenone hydrochloride (CHEBI:8466) has part propafenone(1+) (CHEBI:63650)
propafenone hydrochloride (CHEBI:8466) has role anti-arrhythmia drug (CHEBI:38070)
propafenone hydrochloride (CHEBI:8466) is a hydrochloride (CHEBI:36807)
IUPAC Name
1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one hydrochloride
Synonyms Sources
2-hydroxy-3-[2-(3-phenylpropanoyl)phenoxy]-N-propylpropan-1-aminium chloride IUPAC
Propafenon hydrochlorid ChemIDplus
propafenone HCl ChemIDplus
Brand Names Sources
Arythmol ChEBI
Rythmol KEGG DRUG
Manual Xrefs Databases
D00640 KEGG DRUG
DB01182 DrugBank
View more database links
Registry Numbers Types Sources
34183-22-7 CAS Registry Number ChemIDplus
34183-22-7 CAS Registry Number KEGG DRUG
4343069 Reaxys Registry Number Reaxys
Last Modified
19 January 2012