azelastine hydrochloride (CHEBI:2951)

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ChEBI Name	azelastine hydrochloride

ChEBI ID	CHEBI:2951

Definition	The hydrochloride salt of azelastine.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formulae

C22H24ClN3O.HCl
C22H25Cl2N3O

Net Charge

Average Mass

418.35900

Monoisotopic Mass

417.13747

InChI

InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H

InChIKey

YEJAJYAHJQIWNU-UHFFFAOYSA-N

SMILES

Cl.CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O

Roles Classification
Biological Role(s):	EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34). H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.

Application(s):	platelet aggregation inhibitor A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. bronchodilator agent An agent that causes an increase in the expansion of a bronchus or bronchial tubes. anti-asthmatic drug A drug used to treat asthma. anti-allergic agent A drug used to treat allergic reactions. H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.

ChEBI Ontology
Outgoing	azelastine hydrochloride (CHEBI:2951) has part azelastine (CHEBI:2950) azelastine hydrochloride (CHEBI:2951) has role anti-allergic agent (CHEBI:50857) azelastine hydrochloride (CHEBI:2951) has role anti-asthmatic drug (CHEBI:49167) azelastine hydrochloride (CHEBI:2951) has role bronchodilator agent (CHEBI:35523) azelastine hydrochloride (CHEBI:2951) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964) azelastine hydrochloride (CHEBI:2951) has role H₁-receptor antagonist (CHEBI:37955) azelastine hydrochloride (CHEBI:2951) has role platelet aggregation inhibitor (CHEBI:50427) azelastine hydrochloride (CHEBI:2951) is a hydrochloride (CHEBI:36807)

IUPAC Name

4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride

Synonyms	Sources
4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone monohydrochloride	ChemIDplus
Azelastine HCl	ChemIDplus

Last Modified

21 June 2012