CHEBI:135653 - taltirelin

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ChEBI Name taltirelin
ChEBI ID CHEBI:135653
Definition An oligopeptide comprising of (4S)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid, L-histidine and L-prolinamide joined in sequence by peptide linkages. It is a thyrotropin-releasing hormone (TRH) analog. Its tetrahydrate form is approved in Japan for the treatment of spinal muscular atrophy.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H23N7O5
Net Charge 0
Average Mass 405.415
Monoisotopic Mass 405.17607
InChI InChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29)/t10-,11-,12-/m0/s1
InChIKey LQZAIAZUDWIVPM-SRVKXCTJSA-N
SMILES CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(N)=O
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
Application(s): nootropic agent
Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
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ChEBI Ontology
Outgoing taltirelin (CHEBI:135653) has role analgesic (CHEBI:35480)
taltirelin (CHEBI:135653) has role neuroprotective agent (CHEBI:63726)
taltirelin (CHEBI:135653) has role nootropic agent (CHEBI:66980)
taltirelin (CHEBI:135653) is a oligopeptide (CHEBI:25676)
Incoming taltirelin tetrahydrate (CHEBI:157598) has part taltirelin (CHEBI:135653)
IUPAC Name
N-{[(4S)-1-methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide
INNs Sources
taltirelin WHO MedNet
taltirelina WHO MedNet
taltiréline WHO MedNet
taltirelinum WHO MedNet
Synonyms Sources
1-methyl-(S)-4,5-dihydroorotyl-L-histidyl-L-prolinamide ChEBI
TA 0910 DrugCentral
TA-0910 DrugCentral
Manual Xrefs Databases
102734 ChemSpider
2560 DrugCentral
Taltirelin Wikipedia
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Registry Number Type Source
103300-74-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
23 November 2020