CHEBI:9207 - sotalol hydrochloride

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ChEBI Name sotalol hydrochloride
ChEBI ID CHEBI:9207
Definition A hydrochloride salt that is the monohydrochloride of sotalol. It has both β-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C12H21ClN2O3S
Net Charge 0
Average Mass 308.82500
Monoisotopic Mass 308.09614
InChI InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChIKey VIDRYROWYFWGSY-UHFFFAOYSA-N
SMILES Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing sotalol hydrochloride (CHEBI:9207) has part sotalol(1+) (CHEBI:63647)
sotalol hydrochloride (CHEBI:9207) has role β-adrenergic antagonist (CHEBI:35530)
sotalol hydrochloride (CHEBI:9207) has role anti-arrhythmia drug (CHEBI:38070)
sotalol hydrochloride (CHEBI:9207) is a hydrochloride (CHEBI:36807)
IUPAC Name
N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide hydrochloride
Synonyms Sources
4'-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide monohydrochloride ChemIDplus
4-(2-Isopropylamino-1-hydroxyaethyl)methanesulfonailid hydrochlorid ChemIDplus
isopropylaminohydroxyethylmethanesulfonanilide hydrochloride ChemIDplus
N-(2-hydroxy-2-{4-[(methylsulfonyl)amino]phenyl}ethyl)propan-2-aminium chloride IUPAC
N-isopropyl-β-(4-methanesulfonamidophenyl)ethanolamine hydrochloride ChemIDplus
sotalol HCl ChemIDplus
sotalol monohydrochloride ChEBI
Brand Names Sources
Betapace KEGG DRUG
Betapace AF DrugBank
Manual Xrefs Databases
D01026 KEGG DRUG
DB00489 DrugBank
View more database links
Registry Numbers Types Sources
4279514 Reaxys Registry Number Reaxys
959-24-0 CAS Registry Number KEGG COMPOUND
959-24-0 CAS Registry Number ChemIDplus
Last Modified
28 July 2014