CHEBI:88312 - nefopam hydrochloride

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ChEBI Name nefopam hydrochloride
ChEBI ID CHEBI:88312
Definition A racemate comprising equal amounts of (R)- and (S)-nefopam hydrochloride. A centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H20ClNO
Net Charge 0
Average Mass 289.800
Monoisotopic Mass 289.12334
Roles Classification
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
dopamine uptake inhibitor
A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
adrenergic uptake inhibitor
Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
dopamine uptake inhibitor
A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
adrenergic uptake inhibitor
Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
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ChEBI Ontology
Outgoing nefopam hydrochloride (CHEBI:88312) has part (R)-nefopam hydrochloride (CHEBI:88315)
nefopam hydrochloride (CHEBI:88312) has part (S)-nefopam hydrochloride (CHEBI:88314)
nefopam hydrochloride (CHEBI:88312) has role adrenergic uptake inhibitor (CHEBI:35640)
nefopam hydrochloride (CHEBI:88312) has role dopamine uptake inhibitor (CHEBI:51039)
nefopam hydrochloride (CHEBI:88312) has role non-narcotic analgesic (CHEBI:35481)
nefopam hydrochloride (CHEBI:88312) has role serotonin uptake inhibitor (CHEBI:50949)
nefopam hydrochloride (CHEBI:88312) is a racemate (CHEBI:60911)
IUPAC Names
rac-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-5-ium chloride
rac-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride
Synonyms Sources
(±)-nefopam hydrochloride ChEBI
(RS)-nefopam hydrochloride ChEBI
3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride ChemIDplus
Nefopam HCl ChemIDplus
rac-nefopam hydrochloride ChEBI
Brand Name Source
Acupan KEGG DRUG
Manual Xrefs Databases
D05133 KEGG DRUG
Nefopam Wikipedia
View more database links
Registry Numbers Types Sources
23327-57-3 CAS Registry Number KEGG DRUG
23327-57-3 CAS Registry Number ChemIDplus
3575294 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 October 2015