ketorolac tromethamine (CHEBI:6130)

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ChEBI Name	ketorolac tromethamine

ChEBI ID	CHEBI:6130

Definition	An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C19H24N2O6

Net Charge

Average Mass

376.40370

Monoisotopic Mass

376.16344

InChI

InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2

InChIKey

BWHLPLXXIDYSNW-UHFFFAOYSA-N

SMILES

[NH3+]C(CO)(CO)CO.[O-]C(=O)C1CCn2c1ccc2C(=O)c1ccccc1

Roles Classification
Biological Role(s):	analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. cyclooxygenase 2 inhibitor A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2. cyclooxygenase 1 inhibitor A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1.

Application(s):	analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.

ChEBI Ontology
Outgoing	ketorolac tromethamine (CHEBI:6130) has part Htris (CHEBI:46097) ketorolac tromethamine (CHEBI:6130) has part ketorolac(1−) (CHEBI:76229) ketorolac tromethamine (CHEBI:6130) has role analgesic (CHEBI:35480) ketorolac tromethamine (CHEBI:6130) has role cyclooxygenase 1 inhibitor (CHEBI:50630) ketorolac tromethamine (CHEBI:6130) has role cyclooxygenase 2 inhibitor (CHEBI:50629) ketorolac tromethamine (CHEBI:6130) is a organoammonium salt (CHEBI:46850)

IUPAC Name

1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate

Last Modified

08 November 2013