CHEBI:60831 - epothilone

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ChEBI Name epothilone ChEBI ID CHEBI:60831 Definition Any member of the class of 16-membered macrolide natural products, or their analogues, normally containing a double bond or its epoxide at positions 12-13 and bearing hydroxy groups at positions 4 and 8, methyl groups at positions 5, 5, 7, and 9, an oxo group at position 6, and a 1-(2-substituted-1,3-thiazol-4-yl)prop-1-en-2-yl substituent at position 15. Stars This entity has been manually annotated by the ChEBI Team. Wikipedia License Read full article at Wikipedia Roles Classification Biological Role(s): bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. View more via ChEBI Ontology ChEBI Ontology Outgoing epothilone (CHEBI:60831) has role bacterial metabolite (CHEBI:76969) epothilone (CHEBI:60831) is a β-hydroxy ketone (CHEBI:55380) epothilone (CHEBI:60831) is a 1,3-thiazoles (CHEBI:38418) epothilone (CHEBI:60831) is a macrolide (CHEBI:25106) Incoming (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione (CHEBI:94722) is a epothilone (CHEBI:60831) (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione (CHEBI:95095) is a epothilone (CHEBI:60831) (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-(2-methyl-4-thiazolyl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione (CHEBI:94639) is a epothilone (CHEBI:60831) 9-Oxoepothilone D (CHEBI:220600) is a epothilone (CHEBI:60831) epothilone A (CHEBI:31549) is a epothilone (CHEBI:60831) Epothilone A 3-alpha-D-arabinofuranoside (CHEBI:227234) is a epothilone (CHEBI:60831) Epothilone A9 (CHEBI:202557) is a epothilone (CHEBI:60831) epothilone B (CHEBI:31550) is a epothilone (CHEBI:60831) Epothilone B 3-alpha-D-arabinofuranoside (CHEBI:206409) is a epothilone (CHEBI:60831) Epothilone B10 (CHEBI:204055) is a epothilone (CHEBI:60831) epothilone C (CHEBI:80029) is a epothilone (CHEBI:60831) Epothilone C7 (CHEBI:197760) is a epothilone (CHEBI:60831) Epothilone C9 (CHEBI:200353) is a epothilone (CHEBI:60831) Epothilone C9 3-alpha-D-arabinofuranoside (CHEBI:202057) is a epothilone (CHEBI:60831) epothilone D (CHEBI:29579) is a epothilone (CHEBI:60831) Epothilone D 3-alpha-D-arabinofuranoside (CHEBI:211906) is a epothilone (CHEBI:60831) Epothilone E (CHEBI:197627) is a epothilone (CHEBI:60831) Epothilone F (CHEBI:220411) is a epothilone (CHEBI:60831) Synonym Source epothilones ChEBI Manual Xrefs Databases DE4138042 Patent Epothilone Wikipedia View more database links Last Modified 21 September 2015

General Comment 2010-12-21 Epothilones (named from the structural components epoxide, thiazole and ketone) were first isolated from the common soil myxobacterium Sorangium cellulosum in 1987. They are of interest as anti-cancer drugs; like taxanes, they prevent cancer cells from dividing by interfering with tubulin.