ecothiopate iodide (CHEBI:59849)

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ChEBI Name	ecothiopate iodide

ChEBI ID	CHEBI:59849

Definition	The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C9H23INO3PS

Net Charge

Average Mass

383.22700

Monoisotopic Mass

383.01810

InChI

InChI=1S/C9H23NO3PS.HI/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5;/h6-9H2,1-5H3;1H/q+1;/p-1

InChIKey

OVXQHPWHMXOFRD-UHFFFAOYSA-M

SMILES

[I-].CCOP(=O)(OCC)SCC[N+](C)(C)C

Roles Classification
Biological Role(s):	EC 3.1.1.8 (cholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8). miotic An agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils.

Application(s):	antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. miotic An agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils.

ChEBI Ontology
Outgoing	ecothiopate iodide (CHEBI:59849) has part ecothiopate (CHEBI:4753) ecothiopate iodide (CHEBI:59849) has role antiglaucoma drug (CHEBI:39456) ecothiopate iodide (CHEBI:59849) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733) ecothiopate iodide (CHEBI:59849) has role miotic (CHEBI:51068) ecothiopate iodide (CHEBI:59849) is a iodide salt (CHEBI:24858) ecothiopate iodide (CHEBI:59849) is a quaternary ammonium salt (CHEBI:35273)

IUPAC Name

2-[(diethoxyphosphoryl)sulfanyl]-N,N,N-trimethylethanaminium iodide

Synonyms	Sources
(2-mercaptoethyl)trimethylammonium iodidie O,O-diethyl phosphorothioate	ChEBI
2-[(diethoxyphosphinyl)thio]-N,N,N-trimethylethanaminium iodide	ChEBI
2-diethoxy-phosphinylthioethyl-trimethylammonium iodide	ChemIDplus
diethoxyphosphinylthiocholine iodide	ChEBI
diethoxyphosphoryl-thiocholine iodide	ChemIDplus
ecothiophate iodide	ChemIDplus
N-(2-(diethoxyphosphinylthio)ethyl)trimethylammonium iodide	ChemIDplus
O,O-diethyl S-2-trimethylammonium ethylphosphonothiolate iodide	ChemIDplus
S-(2-(N,N,N-trimethylammonio)ethyl) O,O-diethylphosphorothiolate iodide	ChemIDplus
S-(2-dimethylaminoethyl)-O,O-diethylphosphorothioate methiodide	ChemIDplus
S-β-dimethylaminoethyl-O,O-diethylthionophosphate methiodide	ChEBI

Last Modified

26 July 2010