CHEBI:3395 - carbidopa

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name carbidopa
ChEBI ID CHEBI:3395
Definition The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens α- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:212626
Supplier Information
Download Molfile XML SDF
Formula C10H16N2O5
Net Charge 0
Average Mass 244.24440
Monoisotopic Mass 244.10592
InChI InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
InChIKey QTAOMKOIBXZKND-PPHPATTJSA-N
SMILES O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of aromatic-L-amino-acid decarboxylase (EC 4.1.1.28).
dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
Application(s): antidyskinesia agent
Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
antiparkinson drug
A drug used in the treatment of Parkinson's disease.
dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing carbidopa (CHEBI:3395) has part carbidopa (anhydrous) (CHEBI:39585)
carbidopa (CHEBI:3395) has role antidyskinesia agent (CHEBI:66956)
carbidopa (CHEBI:3395) has role antiparkinson drug (CHEBI:48407)
carbidopa (CHEBI:3395) has role dopaminergic agent (CHEBI:48560)
carbidopa (CHEBI:3395) has role EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor (CHEBI:59321)
carbidopa (CHEBI:3395) is a catechols (CHEBI:33566)
carbidopa (CHEBI:3395) is a hydrate (CHEBI:35505)
carbidopa (CHEBI:3395) is a hydrazines (CHEBI:24631)
carbidopa (CHEBI:3395) is a monocarboxylic acid (CHEBI:25384)
IUPAC Name
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid—water (1/1)
INN Source
carbidopa ChemIDplus
Synonyms Sources
(−)-L-α-hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate ChemIDplus
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate ChEBI
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate ChEBI
(αS)-α-hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid monohydrate ChEBI
(S)-(−)-carbidopa hydrate ChEBI
(S)-carbidopa hydrate ChEBI
carbidopa hydrate ChEBI
carbidopa monohydrate DrugBank
carbidopum monohydricum ChEBI
L-α-(3,4-dihydroxybenzyl)-α-hydrazinopropionic acid monohydrate ChEBI
Manual Xrefs Databases
D00558 KEGG DRUG
DB00190 DrugBank
DE2062285 Patent
DE2062332 Patent
GB940596 Patent
US3462536 Patent
View more database links
Registry Number Type Source
38821-49-7 CAS Registry Number ChemIDplus
Citation Waiting for Citations Type Source
10841799 PubMed citation ChEMBL
Last Modified
29 April 2010