CHEBI:61193 - buclizine dihydrochloride

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ChEBI Name buclizine dihydrochloride
ChEBI ID CHEBI:61193
Definition A hydrochloride salt that is obtained by reaction of buclizine with 2 equivalents of hydrogen chloride.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C28H35Cl3N2
Net Charge 0
Average Mass 505.95000
Monoisotopic Mass 504.18658
InChI InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H
InChIKey SDBHDSZKNVDKNU-UHFFFAOYSA-N
SMILES Cl.Cl.CC(C)(C)c1ccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)cc1
Roles Classification
Biological Role(s): histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
Application(s): central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
local anaesthetic
Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
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ChEBI Ontology
Outgoing buclizine dihydrochloride (CHEBI:61193) has part buclizine(2+) (CHEBI:61192)
buclizine dihydrochloride (CHEBI:61193) has role antiemetic (CHEBI:50919)
buclizine dihydrochloride (CHEBI:61193) has role central nervous system depressant (CHEBI:35488)
buclizine dihydrochloride (CHEBI:61193) has role cholinergic antagonist (CHEBI:48873)
buclizine dihydrochloride (CHEBI:61193) has role histamine antagonist (CHEBI:37956)
buclizine dihydrochloride (CHEBI:61193) has role local anaesthetic (CHEBI:36333)
buclizine dihydrochloride (CHEBI:61193) is a hydrochloride (CHEBI:36807)
IUPAC Name
1-(4-tert-butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine dihydrochloride
Synonyms Sources
1-(4-tert-butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazinediium dichloride IUPAC
1-(p-chlorobenzhydryl)-4-(p-t-butylbenzyl)diethylenediamine dihydrochloride ChemIDplus
1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine dihydrochloride ChemIDplus
buclizine 2HCl ChEBI
buclizine hydrochloride ChemIDplus
Brand Name Source
BUCLADIN-S ChEBI
Manual Xrefs Databases
D02089 KEGG DRUG
DB00354 DrugBank
View more database links
Registry Numbers Types Sources
129-74-8 CAS Registry Number ChemIDplus
129-74-8 CAS Registry Number KEGG DRUG
3810500 Reaxys Registry Number Reaxys
Last Modified
03 February 2011