CHEBI:4858 - estazolam

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name estazolam
ChEBI ID CHEBI:4858
Definition A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:149847
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C16H11ClN4
Net Charge 0
Average Mass 294.73800
Monoisotopic Mass 294.06722
InChI InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
InChIKey CDCHDCWJMGXXRH-UHFFFAOYSA-N
SMILES Clc1ccc-2c(c1)C(=NCc1nncn-21)c1ccccc1
Roles Classification
Biological Role(s): GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing estazolam (CHEBI:4858) has role anticonvulsant (CHEBI:35623)
estazolam (CHEBI:4858) has role anxiolytic drug (CHEBI:35474)
estazolam (CHEBI:4858) has role GABA modulator (CHEBI:50268)
estazolam (CHEBI:4858) is a triazoles (CHEBI:35727)
estazolam (CHEBI:4858) is a triazolobenzodiazepine (CHEBI:35501)
IUPAC Name
8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
INNs Sources
estazolam ChemIDplus
estazolamum ChemIDplus
Synonym Source
8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine ChemIDplus
Manual Xrefs Databases
1056 DrugCentral
D00311 KEGG DRUG
DB01215 DrugBank
DE1955349 Patent
DE2012190 Patent
DE2114441 Patent
Estazolam Wikipedia
US3701782 Patent
View more database links
Registry Numbers Types Sources
1220868 Beilstein Registry Number Beilstein
29975-16-4 CAS Registry Number KEGG DRUG
29975-16-4 CAS Registry Number NIST Chemistry WebBook
29975-16-4 CAS Registry Number ChemIDplus
Citation Waiting for Citations Type Source
7154007 PubMed citation ChEMBL
Last Modified
22 February 2017