perampanel (CHEBI:71013)

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ChEBI Name	perampanel

ChEBI ID	CHEBI:71013

Definition	A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C23H15N3O

Net Charge

Average Mass

349.38470

Monoisotopic Mass

349.12151

InChI

InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H

InChIKey

PRMWGUBFXWROHD-UHFFFAOYSA-N

SMILES

O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N

Roles Classification
Biological Role(s):	AMPA receptor antagonist An antagonist at the AMPA receptor.

Application(s):	anticonvulsant A drug used to prevent seizures or reduce their severity.

ChEBI Ontology
Outgoing	perampanel (CHEBI:71013) has functional parent benzonitrile (CHEBI:27991) perampanel (CHEBI:71013) has role AMPA receptor antagonist (CHEBI:71014) perampanel (CHEBI:71013) has role anticonvulsant (CHEBI:35623) perampanel (CHEBI:71013) is a bipyridines (CHEBI:50511) perampanel (CHEBI:71013) is a nitrile (CHEBI:18379) perampanel (CHEBI:71013) is a pyridone (CHEBI:38183)

Incoming	perampanel hydrate (CHEBI:71015) has part perampanel (CHEBI:71013)

IUPAC Name

2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile

Synonyms	Sources
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one	ChemIDplus
E 2007	ChemIDplus
E2007	ChemIDplus
ER-155055-90	ChemIDplus

Brand Name	Source
Fycompa	KEGG DRUG

Last Modified

22 February 2017