tranilast (CHEBI:77572)

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ChEBI Name	tranilast

ChEBI ID	CHEBI:77572

Definition	An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C18H17NO5

Net Charge

Average Mass

327.33130

Monoisotopic Mass

327.11067

InChI

InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+

InChIKey

NZHGWWWHIYHZNX-CSKARUKUSA-N

SMILES

COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. aryl hydrocarbon receptor agonist An agonist that binds to and activates aryl hydrocarbon receptors (AhRs).

Application(s):	nephroprotective agent Any protective agent that is able to prevent damage to the kidney. anti-allergic agent A drug used to treat allergic reactions. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. hepatoprotective agent Any compound that is able to prevent damage to the liver. anti-asthmatic drug A drug used to treat asthma.

ChEBI Ontology
Outgoing	tranilast (CHEBI:77572) has functional parent anthranilic acid (CHEBI:30754) tranilast (CHEBI:77572) has role anti-allergic agent (CHEBI:50857) tranilast (CHEBI:77572) has role anti-asthmatic drug (CHEBI:49167) tranilast (CHEBI:77572) has role antineoplastic agent (CHEBI:35610) tranilast (CHEBI:77572) has role aryl hydrocarbon receptor agonist (CHEBI:72768) tranilast (CHEBI:77572) has role calcium channel blocker (CHEBI:38215) tranilast (CHEBI:77572) has role hepatoprotective agent (CHEBI:62868) tranilast (CHEBI:77572) has role nephroprotective agent (CHEBI:76595) tranilast (CHEBI:77572) is a amidobenzoic acid (CHEBI:48470) tranilast (CHEBI:77572) is a cinnamamides (CHEBI:23247) tranilast (CHEBI:77572) is a dimethoxybenzene (CHEBI:51681) tranilast (CHEBI:77572) is a secondary carboxamide (CHEBI:140325)

IUPAC Name

2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid

Synonyms	Sources
MK 341	ChemIDplus
MK-341	ChemIDplus
N-(3,4-Dimethoxycinnamoyl)anthranilic acid	ChemIDplus

Brand Name	Source
Rizaben	KEGG DRUG

Last Modified

07 March 2018