CHEBI:66617 - nepalensinol E

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ChEBI Name nepalensinol E
ChEBI ID CHEBI:66617
Definition A stilbenoid isolated from the stems of Kobresia nepalensis and has been shown to exhibit inhibitory activity against topoisomerase II.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C56H44O13
Net Charge 0
Average Mass 924.94080
Monoisotopic Mass 924.27819
InChI InChI=1S/C56H44O13/c57-33-9-1-27(2-10-33)53-49(31-17-37(61)21-38(62)18-31)43-23-41(45(65)25-47(43)67-53)51-44-24-42(46(66)26-48(44)68-55(51)29-5-13-35(59)14-6-29)52-50(32-19-39(63)22-40(64)20-32)54(28-3-11-34(58)12-4-28)69-56(52)30-7-15-36(60)16-8-30/h1-26,49-66H/t49-,50+,51-,52-,53+,54-,55+,56+/m1/s1
InChIKey LQIPZGZUEUXKIL-XLTULDRDSA-N
SMILES Oc1ccc(cc1)[C@H]1O[C@H]([C@@H]([C@@H]1c1cc(O)cc(O)c1)c1cc2[C@H]([C@@H](Oc2cc1O)c1ccc(O)cc1)c1cc2[C@H]([C@@H](Oc2cc1O)c1ccc(O)cc1)c1cc(O)cc(O)c1)c1ccc(O)cc1
Metabolite of Species Details
Kobresia nepalensis (NCBI:txid58223) Found in stem (BTO:0001300). See: PubMed
Roles Classification
Biological Role(s): metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
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ChEBI Ontology
Outgoing nepalensinol E (CHEBI:66617) has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750)
nepalensinol E (CHEBI:66617) has role metabolite (CHEBI:25212)
nepalensinol E (CHEBI:66617) is a 1-benzofurans (CHEBI:38830)
nepalensinol E (CHEBI:66617) is a polyphenol (CHEBI:26195)
nepalensinol E (CHEBI:66617) is a stilbenoid (CHEBI:26776)
IUPAC Name
(2R,2'R,3R,3'R)-3'-(3,5-dihydroxyphenyl)-5-[(2R,3S,4R,5S)-4-(3,5-dihydroxyphenyl)-2,5-bis(4-hydroxyphenyl)tetrahydrofuran-3-yl]-2,2'-bis(4-hydroxyphenyl)-2,2',3,3'-tetrahydro-3,5'-bi-1-benzofuran-6,6'-diol
Registry Number Type Source
10415756 Reaxys Registry Number Reaxys
Citation Waiting for Citations Type Source
16508191 PubMed citation Europe PMC
Last Modified
16 April 2013