MEDICA 16 (CHEBI:149582)

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ChEBI Name	MEDICA 16

ChEBI ID	CHEBI:149582

Definition	An α,ω-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Stan Laulederkind

Supplier Information

Download	Molfile XML SDF

Formula

C20H38O4

Net Charge

Average Mass

342.520

Monoisotopic Mass

342.27701

InChI

InChI=1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)

InChIKey

HYSMCRNFENOHJH-UHFFFAOYSA-N

SMILES

C(O)(CC(CCCCCCCCCCC(CC(O)=O)(C)C)(C)C)=O

Roles Classification
Chemical Role(s):	Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). (via oxoacid )

Biological Role(s):	EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor An EC 6.4.1.* (C1C bond-forming ligase) inhibitor that interferes with the action of acetyl-CoA carboxylase (EC 6.4.1.2). EC 2.3.3.8 (ATP citrate synthase) inhibitor An EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor that interferes with the action of ATP citrate synthase (EC 2.3.3.8). G-protein-coupled receptor agonist An agonist that binds to and activates G-protein-coupled receptors

Application(s):	antilipemic drug A substance used to treat hyperlipidemia (an excess of lipids in the blood). hypoglycemic agent A drug which lowers the blood glucose level.

ChEBI Ontology
Outgoing	MEDICA 16 (CHEBI:149582) has role antilipemic drug (CHEBI:35679) MEDICA 16 (CHEBI:149582) has role EC 2.3.3.8 (ATP citrate synthase) inhibitor (CHEBI:149598) MEDICA 16 (CHEBI:149582) has role EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor (CHEBI:70722) MEDICA 16 (CHEBI:149582) has role G-protein-coupled receptor agonist (CHEBI:70998) MEDICA 16 (CHEBI:149582) has role hypoglycemic agent (CHEBI:35526) MEDICA 16 (CHEBI:149582) is a α,ω-dicarboxylic acid (CHEBI:28383)

IUPAC Name

3,3,14,14-tetramethylhexadecanedioic acid

Synonyms	Sources
β,β'-tetramethylhexadecane-α,ω-dioic acid	ChEBI
β,β'-tetramethylhexadecanedioic acid	ChEBI
MEDIC-16	ChemIDplus
MEDICA-16	ChEBI
MEDICA16	ChEBI

Registry Number	Type	Source
87272-20-6	CAS Registry Number	ChemIDplus

Last Modified

01 May 2020