CHEBI:31429 - colforsin daropate hydrochloride

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ChEBI Name colforsin daropate hydrochloride
ChEBI ID CHEBI:31429
Definition The hydrochloride salt of colforsin daropate. It is a drug used for the treatment of acute heart failure. It directly stimulates adenylate cyclase and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP.
Stars This entity has been manually annotated by the ChEBI Team.
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Formulae C27H43NO8.ClH
C27H43NO8.HCl
Net Charge 0
Average Mass 546.100
Monoisotopic Mass 545.27555
InChI InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChIKey VIRRLEDAYYYTOD-YHEOSNBFSA-N
SMILES Cl.[H][C@@]12[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
Roles Classification
Biological Role(s): adenylate cyclase agonist
Any agonist of one or more of the isoforms of adenylate cyclase (EC 4.6.1.1).
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
cardiotonic drug
A drug that has a strengthening effect on the heart or that can increase cardiac output.
vasodilator agent
A drug used to cause dilation of the blood vessels.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing colforsin daropate hydrochloride (CHEBI:31429) has part colforsin daropate(1+) (CHEBI:166832)
colforsin daropate hydrochloride (CHEBI:31429) has role adenylate cyclase agonist (CHEBI:78548)
colforsin daropate hydrochloride (CHEBI:31429) has role antihypertensive agent (CHEBI:35674)
colforsin daropate hydrochloride (CHEBI:31429) has role cardiotonic drug (CHEBI:38147)
colforsin daropate hydrochloride (CHEBI:31429) has role vasodilator agent (CHEBI:35620)
colforsin daropate hydrochloride (CHEBI:31429) is a hydrochloride (CHEBI:36807)
IUPAC Name
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-6-yl N,N-dimethyl-β-alaninate hydrochloride
Synonyms Sources
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-naphtho[2,1-b]pyran-6-yl N,N-dimethyl-β-alaninate—hydrogen chloride IUPAC
6-(3-dimethylaminopropionyl)forskolin hydrochloride ChEBI
colforsin dapropate HCl ChemIDplus
colforsin dapropate hydrochloride DrugCentral
colforsin daropate HCl DrugCentral
colforsin daropate hydrochloride ChemIDplus
NKH 477 ChemIDplus
NKH-477 ChEBI
NKH477 ChemIDplus
Brand Name Source
Adehl KEGG DRUG
Manual Xrefs Databases
729 DrugCentral
D01697 KEGG DRUG
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Registry Number Type Source
138605-00-2 CAS Registry Number ChemIDplus
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Last Modified
12 November 2020