CHEBI:76232 - sodium meclofenamate monohydrate

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name sodium meclofenamate monohydrate
ChEBI ID CHEBI:76232
Definition A hydrate that is the monohydrate of the sodium salt of meclofenamic acid. It is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C14H12Cl2NNaO3
Net Charge 0
Average Mass 336.14600
Monoisotopic Mass 335.00919
InChI InChI=1S/C14H11Cl2NO2.Na.H2O/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;1H2/q;+1;/p-1
InChIKey QHJLLDJTVQAFAN-UHFFFAOYSA-M
SMILES O.[Na+].Cc1ccc(Cl)c(Nc2ccccc2C([O-])=O)c1Cl
Roles Classification
Biological Role(s): analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Application(s): analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
antirheumatic drug
A drug used to treat rheumatoid arthritis.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing sodium meclofenamate monohydrate (CHEBI:76232) has part sodium meclofenamate (anhydrous) (CHEBI:6711)
sodium meclofenamate monohydrate (CHEBI:76232) has role analgesic (CHEBI:35480)
sodium meclofenamate monohydrate (CHEBI:76232) has role anticonvulsant (CHEBI:35623)
sodium meclofenamate monohydrate (CHEBI:76232) has role antineoplastic agent (CHEBI:35610)
sodium meclofenamate monohydrate (CHEBI:76232) has role antipyretic (CHEBI:35493)
sodium meclofenamate monohydrate (CHEBI:76232) has role antirheumatic drug (CHEBI:35842)
sodium meclofenamate monohydrate (CHEBI:76232) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964)
sodium meclofenamate monohydrate (CHEBI:76232) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
sodium meclofenamate monohydrate (CHEBI:76232) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
sodium meclofenamate monohydrate (CHEBI:76232) is a hydrate (CHEBI:35505)
Synonyms Sources
meclofenamate sodium ChemIDplus
sodium meclofenamate ChemIDplus
Brand Names Sources
Lenidolor ChEBI
Meclodol ChEBI
Meclomen KEGG DRUG
Manual Xref Database
D00169 KEGG DRUG
View more database links
Registry Numbers Types Sources
14619562 Reaxys Registry Number Reaxys
67254-91-5 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
1810520 PubMed citation Europe PMC
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Last Modified
08 November 2013