CHEBI:64323 - memantine hydrochloride

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ChEBI Name memantine hydrochloride
ChEBI ID CHEBI:64323
Definition A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C12H22ClN
Net Charge 0
Average Mass 215.76300
Monoisotopic Mass 215.14408
InChI InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
InChIKey LDDHMLJTFXJGPI-UHFFFAOYSA-N
SMILES Cl.CC12CC3CC(C)(C1)CC(N)(C3)C2
Roles Classification
Biological Role(s): dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
NMDA receptor antagonist
Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
antiparkinson drug
A drug used in the treatment of Parkinson's disease.
dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing memantine hydrochloride (CHEBI:64323) has part memantinium(1+) (CHEBI:64325)
memantine hydrochloride (CHEBI:64323) has role antidepressant (CHEBI:35469)
memantine hydrochloride (CHEBI:64323) has role antiparkinson drug (CHEBI:48407)
memantine hydrochloride (CHEBI:64323) has role dopaminergic agent (CHEBI:48560)
memantine hydrochloride (CHEBI:64323) has role neuroprotective agent (CHEBI:63726)
memantine hydrochloride (CHEBI:64323) has role NMDA receptor antagonist (CHEBI:60643)
memantine hydrochloride (CHEBI:64323) is a hydrochloride (CHEBI:36807)
IUPAC Name
3,5-dimethyladamantan-1-amine hydrochloride
Synonyms Sources
1-Amino-3,5-dimethyladamantane hydrochloride ChemIDplus
3,5-Dimethyl-1-adamantanamine hydrochloride ChemIDplus
3,5-dimethyladamantan-1-aminium chloride IUPAC
3,5-dimethyltricyclo(3.3.1.13,7)decan-1-amine hydrochloride ChemIDplus
Memantine HCl ChemIDplus
memantine.HCl ChEBI
Brand Name Source
Namenda KEGG DRUG
Manual Xrefs Databases
D04905 KEGG DRUG
DB01043 DrugBank
US2011282100 Patent
WO2011125062 Patent
View more database links
Registry Numbers Types Sources
41100-52-1 CAS Registry Number ChemIDplus
41100-52-1 CAS Registry Number KEGG DRUG
6573843 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
19196860 PubMed citation Europe PMC
20013176 PubMed citation Europe PMC
20703320 PubMed citation Europe PMC
20926740 PubMed citation Europe PMC
21213317 PubMed citation Europe PMC
21220675 PubMed citation Europe PMC
21268245 PubMed citation Europe PMC
21792308 PubMed citation Europe PMC
21875407 PubMed citation Europe PMC
21893967 PubMed citation Europe PMC
22214393 PubMed citation Europe PMC
Last Modified
29 March 2012