5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (CHEBI:141354)

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ChEBI Name	5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one

ChEBI ID	CHEBI:141354

ChEBI ASCII Name	5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one

Definition	An isoquinolinol that is 5-hydroxyisoquinolin-1(2H)-one which has been substituted at positions 4 and 8 by phenyl and methoxy groups, respectively. Isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. It displayed weak antibacterial activity.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	R. Stephan

Supplier Information

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Formula

C16H13NO3

Net Charge

Average Mass

267.284

Monoisotopic Mass

267.08954

InChI

InChI=1S/C16H13NO3/c1-20-13-8-7-12(18)14-11(9-17-16(19)15(13)14)10-5-3-2-4-6-10/h2-9,18H,1H3,(H,17,19)

InChIKey

ZOITXTLCKPXXHV-UHFFFAOYSA-N

SMILES

COC=1C=CC(=C2C(=CNC(C12)=O)C3=CC=CC=C3)O

Metabolite of Species	Details
Penicillium sp. R22 (NCBI:txid1856372)	See: PubMed

Roles Classification
Biological Role(s):	antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. fungal metabolite Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.

ChEBI Ontology
Outgoing	5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (CHEBI:141354) has role antifungal agent (CHEBI:35718) 5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (CHEBI:141354) has role fungal metabolite (CHEBI:76946) 5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (CHEBI:141354) is a aromatic ether (CHEBI:35618) 5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (CHEBI:141354) is a isoquinolinol (CHEBI:24923)

IUPAC Names

5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one

8-methoxy-4-phenylisoquinoline-1,5-diol

Synonym	Source
5-hydroxy-8-methoxy-4-phenyl-2H-isoquinolin-1-one	ChEBI

Last Modified

31 May 2022