5-chloro-7-iodoquinolin-8-ol (CHEBI:74460)

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ChEBI Name	5-chloro-7-iodoquinolin-8-ol

ChEBI ID	CHEBI:74460

Definition	A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C9H5ClINO

Net Charge

Average Mass

305.50000

Monoisotopic Mass

304.91044

InChI

InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

InChIKey

QCDFBFJGMNKBDO-UHFFFAOYSA-N

SMILES

Oc1c(I)cc(Cl)c2cccnc12

Roles Classification
Chemical Role(s):	copper chelator A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points. chelator A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.

Biological Role(s):	antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. antiprotozoal drug Any antimicrobial drug which is used to treat or prevent protozoal infections.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antiprotozoal drug Any antimicrobial drug which is used to treat or prevent protozoal infections.

ChEBI Ontology
Outgoing	5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antibacterial agent (CHEBI:33282) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antifungal agent (CHEBI:35718) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antimicrobial agent (CHEBI:33281) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antineoplastic agent (CHEBI:35610) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antiprotozoal drug (CHEBI:35820) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role chelator (CHEBI:38161) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role copper chelator (CHEBI:166831) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a monohydroxyquinoline (CHEBI:38775) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organochlorine compound (CHEBI:36683) 5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organoiodine compound (CHEBI:37142)

IUPAC Name

5-chloro-7-iodoquinolin-8-ol

Synonyms	Sources
5-Chlor-7-jod-8-hydroxy-chinolin	ChemIDplus
5-chloro-7-iodo-8-hydroxyquinoline	ChemIDplus
5-chloro-7-iodo-8-quinolinol	ChemIDplus
5-chloro-8-hydroxy-7-iodoquinoline	ChemIDplus
7-iodo-5-chloro-8-hydroxyquinoline	ChemIDplus
7-iodo-5-chloroxine	ChemIDplus
chloroiodoquin	ChemIDplus
iodochlorhydroxyquinoline	ChemIDplus
iodochlorohydroxyquin	ChemIDplus
iodochloroxyquinoline	ChemIDplus

Last Modified

12 November 2020