SB-202190 (CHEBI:79090)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	SB-202190

ChEBI ID	CHEBI:79090

Definition	A member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-activated protein kinase (MAPK) α and β.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C20H14FN3O

Net Charge

Average Mass

331.34310

Monoisotopic Mass

331.11209

InChI

InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

InChIKey

QHKYPYXTTXKZST-UHFFFAOYSA-N

SMILES

Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1

Roles Classification
Biological Role(s):	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

ChEBI Ontology
Outgoing	SB-202190 (CHEBI:79090) has role apoptosis inducer (CHEBI:68495) SB-202190 (CHEBI:79090) has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor (CHEBI:79091) SB-202190 (CHEBI:79090) is a imidazoles (CHEBI:24780) SB-202190 (CHEBI:79090) is a organofluorine compound (CHEBI:37143) SB-202190 (CHEBI:79090) is a phenols (CHEBI:33853) SB-202190 (CHEBI:79090) is a pyridines (CHEBI:26421)

IUPAC Name

4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol

Synonyms	Sources
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	ChemIDplus
SB 202190	ChemIDplus
SB202190	ChEBI

Last Modified

09 July 2014