terazosin (CHEBI:9445)

ChEBI > Main

Main

ChEBI Ontology

Automatic Xrefs

Reactions

Pathways

Models

ChEBI Name	terazosin

ChEBI ID	CHEBI:9445

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Wikipedia	License

Read full article at Wikipedia

Formula

C19H25N5O4

Net Charge

Average Mass

387.43310

Monoisotopic Mass

387.19065

InChI

InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)

InChIKey

VCKUSRYTPJJLNI-UHFFFAOYSA-N

SMILES

COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. alpha-adrenergic antagonist An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

ChEBI Ontology
Outgoing	terazosin (CHEBI:9445) has role α-adrenergic antagonist (CHEBI:37890) terazosin (CHEBI:9445) has role antihypertensive agent (CHEBI:35674) terazosin (CHEBI:9445) has role antineoplastic agent (CHEBI:35610) terazosin (CHEBI:9445) is a furans (CHEBI:24129) terazosin (CHEBI:9445) is a piperazines (CHEBI:26144) terazosin (CHEBI:9445) is a primary amino compound (CHEBI:50994) terazosin (CHEBI:9445) is a quinazolines (CHEBI:38530)

Incoming	terazosin hydrochloride dihydrate (CHEBI:9446) has part terazosin (CHEBI:9445)

IUPAC Name

6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine

Synonyms	Sources
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine	ChemIDplus
Terazosin	KEGG COMPOUND
Terazosine	KEGG COMPOUND

Last Modified

22 February 2017