CHEBI:60652 - porfimer

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ChEBI Name porfimer
ChEBI ID CHEBI:60652
Definition The purified component of haematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins formed by ether and ester linkages of up to eight porphyrin units (n = 0-6), where R = CH(OH)Me and/or CH=CH2.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula (C32H33N4O4R)0-6.C64H68N8O9R2
Net Charge 0
Average Mass 0.0
Monoisotopic Mass 0.0
Roles Classification
Biological Role(s): antiviral agent
A substance that destroys or inhibits replication of viruses.
cofactor
An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
(via porphyrins )
Application(s): photosensitizing agent
A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
dermatologic drug
A drug used to treat or prevent skin disorders or for the routine care of skin.
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ChEBI Ontology
Outgoing porfimer (CHEBI:60652) has role antineoplastic agent (CHEBI:35610)
porfimer (CHEBI:60652) has role antiviral agent (CHEBI:22587)
porfimer (CHEBI:60652) has role dermatologic drug (CHEBI:50177)
porfimer (CHEBI:60652) has role photosensitizing agent (CHEBI:47868)
porfimer (CHEBI:60652) is a β-substituted porphyrin (CHEBI:52187)
porfimer (CHEBI:60652) is conjugate acid of porfimer anion (CHEBI:60774)
Incoming porfimer anion (CHEBI:60774) is conjugate base of porfimer (CHEBI:60652)
Synonym Source
dihematoporphyrin ether ChemIDplus
Manual Xref Database
DB00707 DrugBank
View more database links
Registry Number Type Source
11092519 Reaxys Registry Number Reaxys
Last Modified
21 March 2019
General Comments
2011-06-29 After addition of sodium hydroxide to pH 7.2 - 7.9, porfimer is used as a photosensitiser in photodynamic therapy of non-small cell lung cancer, oesophageal cancer, and superficial bladder cancer. The drug is administered by slow intravenous injection and accumulates in malignant tissue. After 40-50 hours, it is activated by laser light at 630 nm, delivered to the tumour using a fibre optic guide. Subsequent spin transfer to oxygen molecules within the tissue, generates highly reactive singlet oxygen, and subsequent radical reactions generate superoxide and hydroxyl radicals. Propagation of radical reactions ultimately kills the tumour cells.
2010-11-18 Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units (n = 0-6), where R = CH(OH)Me and/or CH=CH2.